Alkhaibary Ali, AlSufiani Fahd, Alassiri Ali H, Almuntashri Makki, Al Qutub Salma Tarik
College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.
Case Rep Pathol. 2020 May 5;2020:1528698. doi: 10.1155/2020/1528698. eCollection 2020.
Ependymoma is a circumscribed glioma composed of uniform glial cells with bland nuclei in a fibrillary matrix. It is characterized by the presence of perivascular pseudorosettes. Unusual histopathological findings have rarely been reported in ependymomas, 0.5% of all diagnosed cases. Such unusual and exceedingly rare histological findings include osseous or chondroid metaplasia. To the best of our knowledge, only 15 cases of osseocartilaginous ependymomas have been reported in English literature. We report a 3-year-old boy who presented with ataxia, vomiting, and headache for three months. Radiological imaging revealed a posterior fossa lesion. Histopathological examination of the lesion confirmed a posterior fossa ependymoma with chondro-osseous metaplasia. The present case outlines the clinical presentation, histopathological findings, and outcome of chondro-osseous metaplasia in ependymomas. To date, the etiology of chondro-osseous metaplasia in ependymomas remains uncertain. Further research exploring such phenomenon is of paramount importance to explain how these tumors develop.
室管膜瘤是一种界限清楚的胶质瘤，由在纤维性基质中具有淡染细胞核的均匀神经胶质细胞组成。其特征是存在血管周围假菊形团。室管膜瘤中罕见的组织病理学发现很少被报道，占所有确诊病例的0.5%。这种不寻常且极其罕见的组织学发现包括骨化生或软骨化生。据我们所知，英文文献中仅报道了15例骨软骨性室管膜瘤。我们报告一名3岁男孩，出现共济失调、呕吐和头痛3个月。影像学检查显示后颅窝病变。病变的组织病理学检查证实为伴有软骨-骨化生的后颅窝室管膜瘤。本病例概述了室管膜瘤中软骨-骨化生的临床表现、组织病理学发现及转归。迄今为止，室管膜瘤中软骨-骨化生的病因仍不确定。进一步研究探索这种现象对于解释这些肿瘤的发生发展至关重要。
