Pollock A V, Leaper D J, Evans M
Br J Surg. 1977 May;64(5):322-5. doi: 10.1002/bjs.1800640506.
In a series of 410 consecutive potentially contaminated operations, we have compared the relative efficacy of intra-incisional cephaloridine and ampicillin in single doses of 1 g in 2 ml of water. In high risk operations (ileocolorectal surgery, perforated appendicitis, or when the patient has 2-5 cm or more of subcutaneous fat at the site of the incision) cephaloridine prophylaxis resulted in a primary sepsis rate of 14 per cent compared with 36 per cent for ampicillin. In all other patients the two antibiotics were equally effective. Secondary sepsis, following discharge from the wound of a substance other than pus, was equally common in the two groups.
在连续410例可能受污染的手术中，我们比较了单次剂量为1克、溶入2毫升水中的切口内头孢菌素和氨苄青霉素的相对疗效。在高风险手术（回结肠直肠手术、穿孔性阑尾炎，或患者切口部位皮下脂肪达2 - 5厘米或更多）中，头孢菌素预防导致原发性败血症发生率为14%，而氨苄青霉素为36%。在所有其他患者中，两种抗生素效果相同。伤口排出除脓液外其他物质后的继发性败血症在两组中同样常见。
