Gugliandolo Enrico, Peritore Alessio Filippo, D'Amico Ramona, Licata Patrizia, Crupi Rosalia
Department of Chemical, Biological, Pharmaceutical and Environmental Science, University of Messina, 98166 Messina, Italy.
Department of Veterinary Science, University of Messina, 98168 Messina, Italy.
Animals (Basel). 2020 May 21;10(5):898. doi: 10.3390/ani10050898.
Aflatoxin B1 (AFB1) is a mycotoxin commonly present in feed, characterized by several toxic effects. AFB1 seems to have a neurotoxical effect that leads to memory impairment behavior. AFB1 toxicity involves the induction of the oxidative stress pathway, rising lipid peroxidation, and it decreases antioxidant enzyme levels. Hence, in our research, we wanted to evaluate the potential protective effects of quercetin 30 mg/kg in AFB1-mediated toxicity in the brain and the ameliorative effect on behavioral alterations. Oral supplementation with quercetin increased glutathione peroxidase (GSH) levels, superoxidedismutase (SOD) activity and catalase (CAT) in the brain, and it reduced lipid peroxidation in AFB1-treated mice. This antioxidant effect of quercetin in the brains of AFB1-intoxicated mice is reflected in better cognitive and spatial memory capacity, as well as a better profile of anxiety and lethargy disorders. In conclusion, our study suggests that quercetin exerts a preventive role against oxidative stress by promoting antioxidative defense systems and limiting lipid peroxidation.
黄曲霉毒素B1（AFB1）是一种常见于饲料中的霉菌毒素，具有多种毒性作用。AFB1似乎具有神经毒性作用，可导致记忆障碍行为。AFB1的毒性涉及氧化应激途径的诱导、脂质过氧化增加，并降低抗氧化酶水平。因此，在我们的研究中，我们想评估30mg/kg槲皮素对AFB1介导的脑毒性的潜在保护作用以及对行为改变的改善作用。口服补充槲皮素可提高脑中谷胱甘肽过氧化物酶（GSH）水平、超氧化物歧化酶（SOD）活性和过氧化氢酶（CAT），并降低AFB1处理小鼠的脂质过氧化。槲皮素在AFB1中毒小鼠脑中的这种抗氧化作用体现在更好的认知和空间记忆能力，以及更好的焦虑和嗜睡障碍状况。总之，我们的研究表明，槲皮素通过促进抗氧化防御系统和限制脂质过氧化对氧化应激发挥预防作用。
