Harvard Medical School, Boston, Massachusetts, USA.
Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA.
LGBT Health. 2020 Jul;7(5):216-219. doi: 10.1089/lgbt.2019.0313. Epub 2020 May 25.
Acne is a common adverse event among trans-masculine people using testosterone as masculinizing hormone therapy. Isotretinoin is the most effective medication for severe recalcitrant acne and, as such, trans-masculine people with severe acne would likely benefit from treatment with this therapy. Incorporation of gender identity-based questions in iPLEDGE registration documentation will increase information about gender-diverse patients taking isotretinoin in the United States and allow better understanding of teratogenicity risks among these patients. An increase in the number of transgender health providers registered as isotretinoin prescribers in iPLEDGE would increase access to this effective medicine and may improve outcomes in these patients.
痤疮是跨性别男性使用睾丸酮进行男性化激素治疗时常见的不良反应。异维 A 酸是治疗严重难治性痤疮最有效的药物，因此，患有严重痤疮的跨性别男性可能会受益于这种治疗。在 iPLEDGE 注册文件中纳入基于性别认同的问题，将增加美国服用异维 A 酸的性别多样化患者的信息，并更好地了解这些患者的致畸风险。在 iPLEDGE 中注册的跨性别健康提供者的数量增加，将增加获得这种有效药物的机会，并可能改善这些患者的治疗效果。
