Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital Psychiatry II, Medical University of Innsbruck, Innsbruck, Austria.
School of Psychology, Psycho-Oncology Co-operative Sydney, University of Sydney, Camperdown, NSW, 2006, Australia.
Qual Life Res. 2020 Sep;29(9):2485-2495. doi: 10.1007/s11136-020-02536-z. Epub 2020 May 26.
To develop Austrian, Italian, and Polish general population value sets for the EORTC QLU-C10D, a cancer-specific utility instrument based on the EORTC QLQ-C30, and to descriptively compare their index scores for distinct health states.
The QLU-C10D descriptive system comprises 10 health attributes and each can take on 4 levels. A standardised and pre-tested methodology has been applied for valuations including a web-based discrete choice experiment (DCE). It was administered in 1000 general population respondents per country recruited via online panels, aiming at representativeness for core socio-demographic variables.
In all three countries, the attributes with the largest impact on utility were physical functioning, pain, and role functioning. Cancer-specific dimensions with the largest impact were nausea and fatigue or bowel problems. Utility values of the worst health state (i.e. severe problems on all 10 dimension) were -0.111 (Austria), 0.025 (Italy), and 0.048 (Poland). Country-specific utilities differed for a selection of health states across the continuum. Austrian utilities were systematically lower for moderately and severely impaired health states.
QLU-C10D cancer-specific utilities can now be calculated in three more countries. Differences between countries indicate that careful consideration is required when using non-country-specific value sets in economic evaluations.
开发奥地利、意大利和波兰的普通人群 EORTC QLU-C10D 效用值，该工具基于 EORTC QLQ-C30，用于评估癌症患者的效用，描述并比较其对不同健康状态的指数得分。
QLU-C10D 描述系统包括 10 个健康属性，每个属性有 4 个水平。采用了标准化和预先测试的方法进行评估，包括基于网络的离散选择实验（DCE）。该实验在每个国家招募了 1000 名通过在线小组招募的普通人群参与者，旨在代表核心社会人口统计学变量。
在所有三个国家，对效用影响最大的属性是身体功能、疼痛和角色功能。对效用影响最大的癌症特异性维度是恶心和疲劳或肠道问题。最糟糕健康状态（即所有 10 个维度都有严重问题）的效用值分别为 -0.111（奥地利）、0.025（意大利）和 0.048（波兰）。在整个连续体上，一些健康状态的国家特异性效用存在差异。奥地利在中度和重度受损健康状态下的效用值较低。
现在可以在另外三个国家计算 QLU-C10D 癌症特异性效用。国家之间的差异表明，在经济评估中使用非国家特定的效用值时需要谨慎考虑。
