Gerlinger Christoph, Bamber Luke, Leverkus Friedhelm, Schwenke Carsten, Haberland Claudia, Schmidt Gilda, Endrikat Jan
Statistics and Data Insights, Bayer AG, Müllerstr 178, 13353, Berlin, Germany.
Obstetrics and Gynecology, Saarland University, Homburg, Saar, Germany.
BMC Res Notes. 2019 Jan 14;12(1):18. doi: 10.1186/s13104-019-4067-9.
To compare the country-specific value sets of the EQ-5D-5L utility index and to evaluate the impact on the interpretation of clinical study results. Six country value sets from Canada, England, Japan, Korea, Netherlands and Uruguay were obtained from literature. In addition, ten crosswalk value sets were downloaded from the EuroQol.org website.
For each of the 3125 possible health states the difference between the country with the highest index and the country with the lowest index was calculated. The median difference was 0.417 across the health states. When analyzing multinational clinical studies, country-specific value sets should be used to evaluate treatment effects. Additional country-specific analyses are needed.
比较EQ-5D-5L效用指数的各国特定值集，并评估其对临床研究结果解释的影响。从文献中获取了来自加拿大、英国、日本、韩国、荷兰和乌拉圭的六个国家值集。此外，还从EuroQol.org网站下载了十个交叉walk值集。
对于3125种可能的健康状态中的每一种，计算了指数最高的国家与指数最低的国家之间的差异。所有健康状态的中位数差异为0.417。在分析跨国临床研究时，应使用各国特定值集来评估治疗效果。还需要进行额外的各国特定分析。
