使用人体皮肤变白试验对两种分别含有0.1%地奈德或0.05%卤米松的新型外用皮质类固醇乳膏进行效能分级。
Potency ranking of two new topical corticosteroid creams containing 0.1% desonide or 0.05% halometasone utilising the human skin blanching assay.
作者信息
Meyer E, Smith E W, Haigh J M, Kanfer I
机构信息
School of Pharmaceutical Sciences, Rhodes University, Grahamstown, South Africa.
出版信息
Arzneimittelforschung. 1988 Dec;38(12):1840-3.
The human blanching assay was used to assess the potency of two new proprietary corticosteroid creams. The blanching abilities of 0.1% desonide cream and 0.05% halometasone cream were evaluated relative to the blanching elicited by 0.05% clobetasol 17-propionate cream, 0.1% betamethasone 17-valerate cream and 0.05% clobetasone 17-butyrate cream. The results of the trial indicated that the 0.1% desonide cream falls into the potent group of topical corticosteroid preparations and the 0.05% halometasone cream falls into the moderately potent group.
人体皮肤变白试验用于评估两种新型专利皮质类固醇乳膏的效力。相对于0.05%丙酸氯倍他索乳膏、0.1%戊酸倍他米松乳膏和0.05%丁酸氯倍他松乳膏引起的皮肤变白情况，对0.1%地奈德乳膏和0.05%卤米松乳膏的皮肤变白能力进行了评估。试验结果表明，0.1%地奈德乳膏属于强效局部皮质类固醇制剂组，0.05%卤米松乳膏属于中效组。
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