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使用血管收缩生物测定法比较synemol乳膏与其他外用皮质类固醇乳膏。

Comparison of synemol cream and other topical corticosteroid creams using the vasoconstrictor bioassay.

作者信息

Strand L J, Flatman C J, Northway C S, Evans C D

出版信息

Cutis. 1977 May;19(5):689-91.

PMID:862429
Abstract

The human vasoconstrictor bioassay was used to assess the potency of open applications of Synemol cream (0.025%), Diprosone cream (0.05%), Aristocort-A cream (0.5%), and Valisone cream (0.1%). Intensity of vasoconstriction was determined eight, twenty-four, and thirty-two hours after application. Results obtained from the average intensity scores of the three determinations indicated that Synemol cream (0.025%) is actually a more active compound than are Diprosone cream (0.05%), Aristocort-A cream (0.5%), and Valisone cream (0.1%), and that its activity is longer acting.

摘要

采用人体血管收缩生物测定法评估了仙乃乐乳膏(0.025%)、得宝松乳膏(0.05%)、曲安奈德乳膏(0.5%)和卤米松乳膏(0.1%)外用制剂的效力。在用药后8小时、24小时和32小时测定血管收缩强度。从三次测定的平均强度得分得出的结果表明,仙乃乐乳膏(0.025%)实际上比得宝松乳膏(0.05%)、曲安奈德乳膏(0.5%)和卤米松乳膏(0.1%)更具活性,且其活性作用时间更长。

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Cutis. 1977 May;19(5):689-91.
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