Hannigan J H, Fitzgerald L W, Blanchard B A, Riley E P
Center for Behavioral Teratology, State University of New York, Albany 12222.
Alcohol. 1988 Nov-Dec;5(6):431-6. doi: 10.1016/0741-8329(88)90078-x.
We studied the involvement of altered noradrenergic function in the behavioral consequences of fetal ethanol exposure. Pregnant rats were fed a liquid diet containing 35% Ethanol-Derived Calories (EDC), pair-fed a 0% EDC diet with sucrose substituted isocalorically for ethanol, or fed ad lib lab chow. In Experiment 1, offspring from these prenatal treatment groups were injected with the alpha-adrenergic agonist clonidine (0.5 or 2.0 mg/kg) at 10 or 42 days of age and showed age-characteristic, dose-dependent increases in locomotor activity, exploration, forelimb treading, and catalepsy. In Experiment 2, offspring were injected with clonidine (0.25 or 1.0 mg/kg) at 10, 14, or 18 days of age, and locomotor activity and wall-climbing were observed in a warm chamber (33 degrees C). Catalepsy and rectal temperature were also scored. There were no significant differential effects of clonidine on any prenatal treatment group at any age for any measure of activity or rectal temperature. The results do not support the hypothesis that fetal ethanol exposure alters noradrenergic systems in behaviorally significant ways.
我们研究了去甲肾上腺素能功能改变在胎儿乙醇暴露行为后果中的作用。给怀孕大鼠喂食含35%乙醇衍生热量（EDC）的液体饮食，对其进行配对喂养，给予等热量蔗糖替代乙醇的0% EDC饮食，或随意喂食实验室常规饲料。在实验1中，这些产前治疗组的后代在10或42日龄时注射α-肾上腺素能激动剂可乐定（0.5或2.0 mg/kg），并表现出与年龄相关的、剂量依赖性的运动活动、探索、前肢踩踏和僵住症增加。在实验2中，在10、14或18日龄时给后代注射可乐定（0.25或1.0 mg/kg），并在温暖的房间（33摄氏度）中观察运动活动和爬壁情况。还对僵住症和直肠温度进行评分。对于任何活动测量或直肠温度，可乐定在任何年龄对任何产前治疗组均无显著差异影响。结果不支持胎儿乙醇暴露以行为上显著的方式改变去甲肾上腺素能系统这一假设。
