Hannigan J H
Center for Behavioral Teratology, State University of New York at Albany 12222.
Alcohol. 1990 Jan-Feb;7(1):11-6. doi: 10.1016/0741-8329(90)90053-f.
The maturation of sensitivity to the cataleptic actions of selective D1 dopamine receptor blockade was assessed in rats exposed prenatally to ethanol. Pregnant rats received an average of 12.68 g/kg body weight of ethanol per day through a liquid diet. Control dams were either pair-fed an isocaloric liquid diet without ethanol or given ad lib lab chow. Separate groups of male and female offspring of these dams were administered either 0.33 or 1.00 mg/kg of the selective dopamine D1 receptor antagonist SCH 23390 at postnatal days 13, 17 or 21, and catalepsy was measured 0, 15 and 30 min later. The results are consistent with a hypothesis that prenatal ethanol exposure alters behaviors mediated by nigrostriatal dopamine systems. Overall, prenatal ethanol-exposed animals showed less catalepsy than control rats. Further, there is a gender effect in that dopamine antagonist-induced catalepsy matures earlier in normal male than in normal female controls. Prenatal alcohol exposure appears to delay the emergence of mature behavioral responses to dopamine blockade in male but not female rats.
在产前暴露于乙醇的大鼠中，评估了对选择性D1多巴胺受体阻断剂的僵住作用敏感性的成熟情况。怀孕大鼠通过液体饮食平均每天摄入12.68 g/kg体重的乙醇。对照母鼠要么给予不含乙醇的等热量液体饮食进行配对喂养，要么给予随意采食的实验室饲料。这些母鼠的雄性和雌性后代分别在出生后第13、17或21天给予0.33或1.00 mg/kg的选择性多巴胺D1受体拮抗剂SCH 23390，并在0、15和30分钟后测量僵住情况。结果与产前乙醇暴露会改变黑质纹状体多巴胺系统介导的行为这一假设一致。总体而言，产前暴露于乙醇的动物比对照大鼠表现出更少的僵住症状。此外，存在性别效应，即多巴胺拮抗剂诱导的僵住症状在正常雄性大鼠中比在正常雌性对照中成熟得更早。产前酒精暴露似乎会延迟雄性而非雌性大鼠对多巴胺阻断的成熟行为反应的出现。
