State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China.
J Mater Chem B. 2020 Jul 1;8(25):5451-5459. doi: 10.1039/d0tb00679c.
As traditional cancer treatment methods, photodynamic therapy (PDT) and photothermal therapy (PTT) can eliminate primary tumors, but they cannot inhibit extensive tumor metastasis and local recurrence. Herein, in order to prevent intermolecular accumulation and improve photostability, indocyanine green (ICG) is spontaneously adsorbed onto a covalent organic framework (COF) with high affinity through π-π conjugation, and then chicken ovalbumin (OVA) is coated on the surface of COF@ICG via an electrostatic interaction force. The resultant COF@ICG@OVA can ablate primary tumors under 650 nm and 808 nm laser irradiation due to its high photothermal conversion efficiency (η = 35.75%) and ability to produce reactive oxygen species (ROS). Tumor-associated antigens are also produced after combinational PTT/PDT therapy. By further combining with anti-PD-L1 checkpoint blockade therapy, it can effectively eliminate primary tumors and inhibit the metastasis of cancer cells by generating strong immune responses. Taken together, COF@ICG@OVA nanoparticles offer an efficient synergistic therapeutic modality for the treatment of tumor metastasis.
作为传统的癌症治疗方法，光动力疗法（PDT）和光热疗法（PTT）可以消除原发性肿瘤，但它们不能抑制广泛的肿瘤转移和局部复发。在此，为了防止分子间聚集和提高光稳定性，吲哚菁绿（ICG）通过π-π共轭自发吸附在具有高亲和力的共价有机骨架（COF）上，然后通过静电力将鸡卵清白蛋白（OVA）涂覆在 COF@ICG 的表面。由于其高光热转换效率（η=35.75%）和产生活性氧物种（ROS）的能力，所得的 COF@ICG@OVA 可以在 650nm 和 808nm 激光照射下消融原发性肿瘤。联合 PTT/PDT 治疗后也会产生肿瘤相关抗原。通过进一步与抗 PD-L1 检查点阻断治疗相结合，它可以通过产生强烈的免疫反应，有效地消除原发性肿瘤并抑制癌细胞的转移。总之，COF@ICG@OVA 纳米粒子为治疗肿瘤转移提供了一种有效的协同治疗方式。
