Jo Hong Li, Jung Yuchul, Suh Byung-Fhy, Cho Eunbyul, Kim Kyungtae, Kim Eunjoo
AMOREPACIFIC R&D Center, Yongin-si, Korea.
Institute d'Expertise Clinique Korea, Gyeonggi-do, Korea.
J Cosmet Dermatol. 2020 Sep;19(9):2438-2443. doi: 10.1111/jocd.13508. Epub 2020 Jun 16.
Blue light from electronic devices enriched with a peak at 456 nm affects circadian rhythm and antioxidant balance of skin, necessitating the study of photoprotection against the 456-nm blue light.
This study aims to report that blue light (456 nm) can cause skin pigmentation and proposes a new clinical evaluation method for blue light (456 nm) protection based on the skin pigmentation level.
PATIENTS/METHODS: We developed a clinical device (ABC device ) that emits blue light (peak = 456 nm). Based on the minimal persistent pigment darkening dose (MPPD) determined from visual evaluation and melanin index measurements, we proposed the "protection grade of blue light (PB)" guideline to assess the protective ability of skin against blue light.
Human skin irradiated with blue light (456 nm) showed a light dose-dependent degree of pigmentation. The MPPD on unprotected and protected skin was 135 J/cm or 180 J/cm and 135-225 J/cm , respectively. The ABC device and the proposed clinical method were used to test the four blue light blocking assessments of TiO . Consequently, the inorganic filter with TiO effectively blocked the blue light (456 nm). The AP product demonstrated the ability to block blue light by 1.15 times (PB = 1.15), which significantly lowered the melanin index of the skin after irradiation as compared to that of the unprotected skin (P < .001).
We propose an objective clinical evaluation method for blue light protection. This study elucidates the properties of blue light blockers for customers suffering from blue light pollution.
富含456纳米峰值的电子设备发出的蓝光会影响昼夜节律和皮肤的抗氧化平衡，因此有必要研究针对456纳米蓝光的光保护作用。
本研究旨在报告蓝光（456纳米）可导致皮肤色素沉着，并基于皮肤色素沉着水平提出一种新的针对蓝光（456纳米）防护的临床评估方法。
患者/方法：我们开发了一种发射蓝光（峰值 = 456纳米）的临床设备（ABC设备）。基于通过视觉评估和黑色素指数测量确定的最小持续色素沉着剂量（MPPD），我们提出了“蓝光防护等级（PB）”指南，以评估皮肤对蓝光的防护能力。
用蓝光（456纳米）照射的人体皮肤显示出光剂量依赖性色素沉着程度。未防护和防护皮肤的MPPD分别为135焦耳/平方厘米或180焦耳/平方厘米以及135 - 225焦耳/平方厘米。使用ABC设备和所提出的临床方法对二氧化钛的四种蓝光阻隔评估进行了测试。因此，含二氧化钛的无机滤光片有效阻隔了蓝光（456纳米）。AP产品显示出阻隔蓝光的能力为1.15倍（PB = 1.15），与未防护皮肤相比，照射后皮肤的黑色素指数显著降低（P <.001）。
我们提出了一种客观的蓝光防护临床评估方法。本研究阐明了针对受蓝光污染影响的消费者的蓝光阻隔剂的特性。
