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肾细胞癌中的脂质：靶向的蜂王？

Lipid in Renal Carcinoma: Queen Bee to Target?

机构信息

Department of Radiation Oncology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

Department of Radiation Oncology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

出版信息

Trends Cancer. 2020 Jun;6(6):448-450. doi: 10.1016/j.trecan.2020.02.017. Epub 2020 Mar 17.

DOI:10.1016/j.trecan.2020.02.017
PMID:32459999
Abstract

Clear cell renal cell carcinoma (ccRCC) is the most common renal cancer subtype, characterized by a lipid storage phenotype. We found that carnitine palmitoyltransferase 1A (CPT1A), the rate-limiting enzyme of mitochondrial fatty acid (FA) transport, is repressed by hypoxia-inducible factors (HIFs), reducing FA oxidation (FAO). Altering lipid metabolism may be a new therapeutic avenue in ccRCC.

摘要

透明细胞肾细胞癌（ccRCC）是最常见的肾癌亚型，其特征是脂质储存表型。我们发现肉毒碱棕榈酰基转移酶 1A（CPT1A），即线粒体脂肪酸（FA）转运的限速酶，受到缺氧诱导因子（HIFs）的抑制，从而减少 FA 氧化（FAO）。改变脂质代谢可能是 ccRCC 的一种新的治疗途径。

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