非小细胞肺癌液体活检的现状与未来展望
Current status and future perspectives of liquid biopsy in non-small cell lung cancer.
作者信息
Chang Sunhee, Hur Jae Young, Choi Yoon-La, Lee Chang Hun, Kim Wan Seop
机构信息
Department of Pathology, Inje University Ilsan Paik Hospital, Goyang, Korea.
Department of Pathology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.
出版信息
J Pathol Transl Med. 2020 May;54(3):204-212. doi: 10.4132/jptm.2020.02.27. Epub 2020 Apr 15.
Abstract
With advances in target therapy, molecular analysis of tumors is routinely required for treatment decisions in patients with advanced non-small cell lung cancer (NSCLC). Liquid biopsy refers to the sampling and analysis of circulating cell-free tumor DNA (ctDNA) in various body fluids, primarily blood. Because the technique is minimally invasive, liquid biopsies are the future in cancer management. Epidermal growth factor receptor (EGFR) ctDNA tests have been performed in routine clinical practice in advanced NSCLC patients to guide tyrosine kinase inhibitor treatment. In the near future, liquid biopsy will be a crucial prognostic, predictive, and diagnostic method in NSCLC. Here we present the current status and future perspectives of liquid biopsy in NSCLC.
摘要
随着靶向治疗的进展，对于晚期非小细胞肺癌（NSCLC）患者，肿瘤的分子分析已成为治疗决策的常规要求。液体活检是指对各种体液（主要是血液）中循环游离肿瘤DNA（ctDNA）进行采样和分析。由于该技术具有微创性，液体活检是癌症管理的未来发展方向。表皮生长因子受体（EGFR）ctDNA检测已在晚期NSCLC患者的常规临床实践中开展，以指导酪氨酸激酶抑制剂治疗。在不久的将来，液体活检将成为NSCLC中至关重要的预后、预测和诊断方法。在此，我们介绍NSCLC液体活检的现状和未来展望。
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