Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
J Am Soc Cytopathol. 2020 Nov-Dec;9(6):586-595. doi: 10.1016/j.jasc.2020.04.005. Epub 2020 Apr 25.
Acinar cell carcinoma (ACC) is a rare malignancy of the pancreas with unique clinical, molecular, and morphologic characteristics. Clinically, these cancers can present with hypersecretory syndrome caused by the release of lipase into the circulation. Surgical resection is the treatment of choice for patients with organ-confined disease; however, with recent advances in precision medicine, therapies targeting the distinct molecular profile of ACC are on the horizon. Cytomorphologic features of ACC have been well described in the literature; and in conjunction with available clinical data and appropriate ancillary studies, an accurate diagnosis can be rendered in most instances. The aim of the current article is to present a comprehensive review of ACC based on available literature while attempting to shed light on some of its key histologic and cytologic characteristics.
腺泡细胞癌（ACC）是一种罕见的胰腺恶性肿瘤，具有独特的临床、分子和形态学特征。临床上，这些癌症可因脂肪酶释放到循环中而引起分泌过多综合征。手术切除是局限于器官疾病患者的治疗选择；然而，随着精准医学的最新进展，针对 ACC 独特分子特征的治疗方法即将出现。ACC 的细胞形态特征在文献中已有很好的描述；并且结合可用的临床数据和适当的辅助研究，大多数情况下都可以做出准确的诊断。本文旨在根据现有文献对 ACC 进行全面综述，同时试图阐明其一些关键的组织学和细胞学特征。
