Eagel B A, Stier S A, Wakem C
Department of Medicine, New Britain General Hospital, CT 06050.
Clin Nucl Med. 1988 Dec;13(12):869-73. doi: 10.1097/00003072-198812000-00004.
Uptake of Tc-99m MDP by extraskeletal tissues is a rare, serendipitous finding during bone scanning studies. It can be clinically correlated with the presence of hypercalcemia in association with renal failure, as may occur in multiple myeloma. While the precise mechanism of non-osseous uptake of MDP is not certain, it may represent metastatic calcification based upon histological examination. A critical calcium-phosphate ion product appears to be requisite for deposition within soft tissues, and all cases in the literature for which data were available exceeded this ion product value. While MDP bone scanning is not generally useful in the diagnosis or staging of multiple myeloma, these findings may indicate secondary effects of the disease. The authors report the first case of liver, spleen, and lung uptake by MDP in a patient with hypercalcemia secondary to multiple myeloma, with a review of the literature.
在骨扫描研究中，骨骼外组织摄取Tc-99m MDP是一种罕见的意外发现。它在临床上可能与肾衰竭伴高钙血症相关，如在多发性骨髓瘤中可能出现的情况。虽然MDP非骨摄取的确切机制尚不确定，但根据组织学检查，它可能代表转移性钙化。软组织内沉积似乎需要临界钙磷离子乘积，且文献中所有可获得数据的病例均超过了该离子乘积值。虽然MDP骨扫描通常对多发性骨髓瘤的诊断或分期无用，但这些发现可能提示该疾病的继发效应。作者报告了首例继发于多发性骨髓瘤的高钙血症患者出现肝脏、脾脏和肺部摄取MDP的病例，并对文献进行了综述。
