Division of Nutrition, St. John's Research Institute, St. John's National Academy of Health Sciences, Bengaluru, Karnataka, India.
Department of Pharmaceutics, Karnataka College of Pharmacy, Bengaluru, Karnataka, India.
Indian J Med Res. 2020 Apr;151(4):371-374. doi: 10.4103/ijmr.IJMR_1464_18.
BACKGROUND & OBJECTIVES: Iron supplementation is widely used public health measure to manage iron deficiency anaemia. In India, enteric-coated iron tablets are administered to adolescent boys and girls to avoid adverse effects such as gastritis, which reduces compliance, but this may result in poor iron absorption. Data on the absorption of iron from enteric-coated ferrous sulphate tablets are lacking. The present study using stable isotopic approach was aimed to measure iron absorption in iron deficient women.
Iron absorption was measured from stable isotope-labelled enteric-coated ferrous sulphate (Fe, ECFS) and uncoated ferrous sulphate (Fe, UCFS) tablets in iron-deficient (n=9) women, aged 18-40 yr with no infection or inflammation. The two types of tablets (ECFS and UCFS) were administered on consecutive days, 60 min after breakfast, and the sequence being random. Blood samples were collected before dosing, and on day 15, to measure iron absorption from the shift in iron isotopic ratios in haemoglobin.
Eight women completed the iron absorption study. Iron absorption was found to be significantly lower in ECFS compared to UCFS (3.5 vs. 12%, P <0.05) consumption.
INTERPRETATION & CONCLUSIONS: Our study showed poor iron bioavailability from ECFS, and supplementation programmes may consider UCFS tablets for better haematological outcomes.
铁补充剂是广泛用于公共卫生措施的一种方法，旨在治疗缺铁性贫血。在印度，给青少年男女服用肠溶性铁片剂，以避免胃炎等不良反应，从而降低了铁的吸收率，但这可能导致铁吸收不良。目前缺乏关于肠溶性硫酸亚铁片剂中铁吸收的数据。本研究采用稳定同位素方法，旨在测量缺铁女性的铁吸收率。
本研究纳入了 9 名年龄在 18-40 岁之间、无感染或炎症的缺铁女性，测量了稳定同位素标记的肠溶性硫酸亚铁（Fe，ECFS）和非包衣硫酸亚铁（Fe，UCFS）片剂的铁吸收率。两种片剂（ECFS 和 UCFS）在早餐后 60 分钟内连续服用，服用顺序随机。在给药前和第 15 天采集血样，以测量血红蛋白中铁同位素比值的变化，从而确定铁的吸收率。
8 名女性完成了铁吸收率研究。与 UCFS 相比，ECFS 的铁吸收率明显较低（3.5% vs. 12%，P <0.05）。
我们的研究表明，ECFS 的铁生物利用度较差，补充计划可能需要考虑 UCFS 片剂，以获得更好的血液学结果。
