经典一线及挽救方案难治的急性淋巴细胞白血病的治疗
Treatment of Acute Lymphoid Leukemia Refractory to Classic First-Line and Rescue Protocols.
作者信息
Russo Flávia Tobaldini, Macedo Maria Cristina Martins de Almeida, Fernades Pedro Amoedo, Okada Larissa Yukari, da Silva Lucas Augusto Monetta, Simões Camila Menin, Cavalcante Jamilla Neves, Simões Aline de Almeida, Almeida Manuella de Souza Sampaio, Lopes Maricy Almeida Viol Ferreira, da Silva Roberto Luiz
机构信息
Instituto Brasileiro de Controle do Câncer (IBCC), São Paulo, Brazil.
Bio Sana`s serviços Médicos, São Paulo, Brazil.
出版信息
Int J Hematol Oncol Stem Cell Res. 2020 Apr 1;14(2):123-126.
Acute Lymphoblastic Leukemia is a very aggressive malignant disorder of lymphoid cells in adults, with recurrence (30 to 60% of the cases) after the initial treatment. Until this moment, there is no gold standard therapy for the treatment of adult patients with acute relapsed/refractory lymphoblastic leukemia. In this case report, we describe two cases of relapsed leukemia: one of lymphocytic leukemia B and one of trilineage leukemia, which presented a satisfactory response to treatment with Bortezomib associated with Vincristine, Dexamethasone, and Bendamustine.
急性淋巴细胞白血病是成人中一种极具侵袭性的淋巴细胞恶性疾病，初始治疗后会复发（30%至60%的病例）。到目前为止，对于治疗成人急性复发/难治性淋巴细胞白血病尚无金标准疗法。在本病例报告中，我们描述了两例复发性白血病：一例B淋巴细胞白血病和一例三系白血病，它们对硼替佐米联合长春新碱、地塞米松和苯达莫司汀治疗呈现出令人满意的反应。
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