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用于下尿路功能障碍的植入式无线无电池膀胱压力监测系统的研发

Development of an Implantable Wireless and Batteryless Bladder Pressure Monitor System for Lower Urinary Tract Dysfunction.

作者信息

Zhong Yihua, Qian Bolin, Zhu Yaguang, Ren Zhaohui, Deng Junming, Liu Jinghua, Bai Qianrui, Zhang Xu

机构信息

1School of Biomedical EngineeringCapital Medical UniversityBeijing100069China.

2Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical ApplicationCapital Medical UniversityBeijing100069China.

出版信息

IEEE J Transl Eng Health Med. 2019 Oct 14;8:2500107. doi: 10.1109/JTEHM.2019.2943170. eCollection 2020.

DOI:10.1109/JTEHM.2019.2943170
PMID:32461841
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7241870/
Abstract

BACKGROUND

Closed-loop neuromodulation based on bladder pressure is an effective therapy for lower urinary tract dysfunction. The catheter-based cystometry normally used for bladder pressure measurement is not conducive to patient health because it will bring great mental stress to the patient and increase the risk of infection.

METHOD

This paper designs and implements an implantable wireless and batteryless bladder pressure monitor system that monitors bladder storage in real time by implanting a miniature packaged sensor which transmits the feedback signal to the external receiver through BLE (Bluetooth Low Energy). The implanted part is powered by a dedicated magnetic resonance based wireless power transmission system, which means no battery is needed.

RESULTS

The maximum distance to which power can be transmitted is 7cm. The in vitro experiment proves that the system performance can meet the requirement of bladder pressure monitoring. The animal experiment uses rabbits as a model to verify the effectiveness of the system. After implantation, this system can work for a long time without replacing the battery.

CONCLUSION

This system can monitor the pressure of the bladder and provide a basis for Closed-loop neuromodulation in patients with lower urinary tract dysfunction.

摘要

背景

基于膀胱压力的闭环神经调节是治疗下尿路功能障碍的有效方法。通常用于测量膀胱压力的基于导管的膀胱测压法不利于患者健康，因为它会给患者带来很大的精神压力并增加感染风险。

方法

本文设计并实现了一种可植入的无线无电池膀胱压力监测系统，该系统通过植入一个微型封装传感器实时监测膀胱储尿情况，该传感器通过低功耗蓝牙（BLE）将反馈信号传输到外部接收器。植入部分由基于磁共振的专用无线电力传输系统供电，这意味着无需电池。

结果

电力传输的最大距离为7厘米。体外实验证明该系统性能可满足膀胱压力监测要求。动物实验以兔子为模型验证了该系统的有效性。植入后，该系统无需更换电池即可长时间工作。

结论

该系统可监测膀胱压力，为下尿路功能障碍患者的闭环神经调节提供依据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c10/7241870/3d8ac4b789a0/zhang14ab-2943170.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c10/7241870/b420391b6cc2/zhang4ab-2943170.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c10/7241870/3715b0234d27/zhang5-2943170.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c10/7241870/e3739a80ba0c/zhang6-2943170.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c10/7241870/aa55a121d43e/zhang7ab-2943170.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c10/7241870/7e1e17f81c8c/zhang8ab-2943170.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c10/7241870/9451653292b9/zhang9ab-2943170.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c10/7241870/077052f324ce/zhang10-2943170.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c10/7241870/82d892a2d0f6/zhang11ab-2943170.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c10/7241870/e377ae99071d/zhang12-2943170.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c10/7241870/d1e327430183/zhang13ab-2943170.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c10/7241870/3d8ac4b789a0/zhang14ab-2943170.jpg

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