Guo Xueguang, Liu Gang, Xie Xiaoping, Li Jing, Hou Zehui, Gu Yanhong, Yu Lijiang
Department of Medical Oncology, Chinese PLA General Hospital, Beijing, China.
Department of Hepatobiliary & Enteric Surgery, Xiangya Hospital, Central South University, Changsha, China.
Iran J Public Health. 2020 Feb;49(2):257-266.
We aimed to detect IL-17, MMP-9 and CD23 in serum of patients with colorectal cancer to provide some proper references for diagnosis and treatment of this disease.
Overall, 287 patients with colorectal cancer were collected in the Digestive Surgery Department of Chinese PLA General Hospital, Beijing, China from January 2017 to November 2018 and were used as the study group, meanwhile, 200 people who took physical examination in the same period were used as the control group. They were retrospectively analyzed. The concentrations of IL-17, MMP-9 and CD23 in serum were detected by ELISA 10 d before and after treatment and 30 d after treatment. The relationship between IL-17, MMP-9 and CD23 concentration and clinicopathology was analyzed.
The concentrations of CD23, IL-17 and MMP-9 in peripheral blood of the patients in the study group were significantly higher than those in the control group (<0.001). IL-17, MMP-9 and CD23 were negatively correlated with treatment time and pathological features in the study group (<0.001).
The concentrations of IL-17, MMP-9 and CD23 obviously increased in peripheral blood of patients with colorectal cancer, the three were negatively correlated with treatment time and were significantly correlated with TNM staging and differentiation degree of colorectal cancer. It is expected to estimate the illness.
我们旨在检测结直肠癌患者血清中的白细胞介素-17（IL-17）、基质金属蛋白酶-9（MMP-9）和CD23，为该疾病的诊断和治疗提供适当参考。
2017年1月至2018年11月期间，在中国北京解放军总医院消化外科收集了287例结直肠癌患者作为研究组，同时，将同期进行体检的200人作为对照组。对其进行回顾性分析。在治疗前10天、治疗后10天和治疗后30天，通过酶联免疫吸附测定法（ELISA）检测血清中IL-17、MMP-9和CD23的浓度。分析IL-17、MMP-9和CD23浓度与临床病理之间的关系。
研究组患者外周血中CD23、IL-17和MMP-9的浓度显著高于对照组（<0.001）。在研究组中，IL-17、MMP-9和CD23与治疗时间和病理特征呈负相关（<0.001）。
结直肠癌患者外周血中IL-17、MMP-9和CD23的浓度明显升高，三者与治疗时间呈负相关，且与结直肠癌的TNM分期和分化程度显著相关。有望用于评估病情。
