麻疹病毒第 24 基因型 D11 的全基因组序列分析。

Whole-genome sequence analysis of the 24th genotype D11 of measles virus.

机构信息

NHC (National health commission), Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, CDC China, WHO WPRO Regional Reference Measles/Rubella Laboratory, Beijing, China.

Center for Biosafety Mega-Science, Chinese Academy of Sciences, Beijing, China.

出版信息

Arch Virol. 2020 Aug;165(8):1895-1898. doi: 10.1007/s00705-020-04671-x. Epub 2020 May 27.

DOI:10.1007/s00705-020-04671-x

PMID:32462283

Abstract

We previously reported genotype D11 strains of measles virus that were first isolated from a measles outbreak associated with imported cases in Yunnan province of China by Zhang et al. (Emerg Infect Dis 16(6):943-7, 2010). Genotype D11 has been identified as the 24th genotype of the WHO reference strains. In this study, we sequenced the whole genome of a D11 strain. Phylogenetic analysis using the complete genome sequences of D11 and other reference strains showed that the D11 strain formed a distinct branch that was distant from the other genotypes and was most closely related to the reference strain D7. The M-F non-coding region (NCR) and the N450 coding region sequence (CDS) were found to be the most variable regions. This report provides basic genetic data on genotype D11 for further study of measles evolution and the support for measles elimination.

摘要

我们之前报道了由张等人从中国云南省与输入病例相关的麻疹暴发中首次分离到的麻疹病毒基因型 D11 株。（《新发传染病》16(6):943-7, 2010）。基因型 D11 已被确认为世卫组织参考株的第 24 个基因型。在这项研究中，我们对 D11 株的全基因组进行了测序。使用 D11 和其他参考株的完整基因组序列进行的系统进化分析表明，D11 株形成了一个与其他基因型明显不同的分支，与参考株 D7 最为密切相关。M-F 非编码区（NCR）和 N450 编码区序列（CDS）被发现是最具变异性的区域。本报告为进一步研究麻疹进化和支持消除麻疹提供了基因型 D11 的基本遗传数据。