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强化物病理学:对药物滥用干预的启示

Reinforcer Pathology: Implications for Substance Abuse Intervention.

作者信息

Bickel Warren K, Athamneh Liqa N, Snider Sarah E, Craft William H, DeHart William B, Kaplan Brent A, Basso Julia C

机构信息

Addiction Recovery Research Center, Fralin Biomedical Research Institute, Roanoke, VA, USA.

Center for Transformative Research on Health Behaviors, Fralin Biomedical Research Institute, Roanoke, VA, USA.

出版信息

Curr Top Behav Neurosci. 2020;47:139-162. doi: 10.1007/7854_2020_145.

Abstract

The rate at which individuals discount future rewards (i.e., discounting rate) is strongly associated with their propensity for substance abuse as well as myriad other negative health behaviors. An excessive preference for immediately available rewards suggests a shortened time horizon in which immediate rewards are overvalued and future, potentially negative consequences are undervalued. This review outlines Reinforcer Pathology Theory (i.e., the interaction between excessive preference for immediately available rewards and the overvaluation of a particular commodity that offers brief, intense reinforcement), its neurobiological/behavioral underpinnings, and its implications for treating substance use disorders. In doing so, the current review provides an overview of a variety of ways in which interventions have been used to manipulate aspects of reinforcer pathology in an individual, including narrative theory, framing manipulations, and neuromodulation (e.g., working memory training, TMS) which may serve as promising avenues for the modulation of the temporal window and/or valuation of reinforcers.

摘要

个体对未来奖励的折扣率(即贴现率)与他们药物滥用的倾向以及无数其他负面健康行为密切相关。对即时可得奖励的过度偏好表明时间跨度缩短,其中即时奖励被高估,而未来潜在的负面后果被低估。本综述概述了强化物病理学理论(即对即时可得奖励的过度偏好与对提供短暂、强烈强化的特定商品的高估之间的相互作用)、其神经生物学/行为学基础及其对治疗物质使用障碍的意义。在此过程中,当前综述提供了各种干预措施的概述,这些干预措施已被用于操纵个体强化物病理学的各个方面,包括叙事理论、框架操纵和神经调节(如工作记忆训练、经颅磁刺激),这些可能是调节强化物的时间窗口和/或估值的有前景的途径。

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