Li Dan, Zhang Tian, Lu Jinjian, Peng Cheng, Lin Ligen
State Key Laboratory of Southwestern Characteristic Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau.
Crit Rev Food Sci Nutr. 2020 May 28:1-19. doi: 10.1080/10408398.2020.1768044.
Adipose tissue, an endocrine and paracrine organ, plays critical roles in the regulation of whole-body metabolic homeostasis. Obesity is accompanied with a chronic low-grade inflammation status in adipose tissue, which disrupts its endocrine function and results in metabolic derangements, such as type 2 diabetes. Dietary bioactive components, such as flavonoids, polyphenols and unsaturated fatty acids from fruits and vegetables, have been widely revealed to alleviate both systemic and adipose tissue inflammation, and improve metabolic disorders. Remarkably, some dietary bioactive components mitigate the inflammatory response in adipocytes, macrophages, and other immune cells, and modulate the crosstalk between adipocytes and macrophages or other immune cells, in adipose tissue. Epidemiological and preclinical studies related to these substances have indicated beneficial effects on adipose tissue inflammation. The main purpose of this review is to provide a comprehensive and up-to-date state of knowledge on dietary components targeting adipose tissue inflammation and their underlying mechanisms. These natural products have great potential to be developed as functional food or lead compounds for treating and/or preventing metabolic disorders.
脂肪组织作为一个内分泌和旁分泌器官，在全身代谢稳态的调节中发挥着关键作用。肥胖伴随着脂肪组织的慢性低度炎症状态，这会破坏其内分泌功能并导致代谢紊乱，如2型糖尿病。来自水果和蔬菜的饮食生物活性成分，如黄酮类化合物、多酚和不饱和脂肪酸，已被广泛证实可减轻全身和脂肪组织炎症，并改善代谢紊乱。值得注意的是，一些饮食生物活性成分可减轻脂肪细胞、巨噬细胞和其他免疫细胞中的炎症反应，并调节脂肪组织中脂肪细胞与巨噬细胞或其他免疫细胞之间的相互作用。与这些物质相关的流行病学和临床前研究表明，它们对脂肪组织炎症具有有益作用。本综述的主要目的是提供关于针对脂肪组织炎症的饮食成分及其潜在机制的全面且最新的知识状态。这些天然产物具有巨大的潜力，可被开发为功能性食品或用于治疗和/或预防代谢紊乱的先导化合物。
