Department of Human Physiology, Medical University of Lublin, Lublin, Poland.
Department of Psychiatry, Psychotherapy and Early Intervention, Medical University of Lublin, Lublin, Poland.
World J Biol Psychiatry. 2021 Mar;22(3):203-213. doi: 10.1080/15622975.2020.1774652. Epub 2020 Jun 22.
The role of physical activity in anorexia nervosa (AN) treatment has been investigated. Muscle strength (MS) reflects physical condition and can predict AN patients' response to this novel treatment approach. This study was intended to find bioelectrical impedance analysis (BIA) parameters that predict AN patients' MS.
The study included 42 AN patients and 42 healthy ones in the control group. BIA parameters that predict MS were assessed by dividing AN patients into groups by their hand grip strength test score (higher/lower than 22.5 kg).
The highest accuracy for distinguishing AN subjects from the control group was achieved by cell membrane capacitance (AUC = 0.916), impedance at 200 kHz and 5 kHz ratio (AUC = 0.924), phase angle (PA) 5 kHz (AUC = 0.906) and PA 50 kHz (AUC = 0.919). The low MS group had significantly lower values of PA 50 kHz (mean: 4.03 ± 0.80° vs. 4.58 ± 0.65°; = 0.032) and fat-free mass index (mean: 12.22 ± 1.41 kg/m vs. 13.14 ± 0.94 kg/m; = 0.026). In the univariate model, PA 50 kHz ≥4.037° was associated with the lowest chance of muscle weakness (OR = 0.230; = 0.005). In the multivariate analysis, PA 50 kHz was the only significant factor of MS (OR = 0.01; = 0.027).
PA 50 kHz is the best BIA parameter to predict MS in AN patients. It could be useful for assessment before physical activity treatment application.
运动在神经性厌食症（AN）治疗中的作用已被研究。肌肉力量（MS）反映了身体状况，可以预测 AN 患者对这种新治疗方法的反应。本研究旨在寻找生物电阻抗分析（BIA）参数来预测 AN 患者的 MS。
该研究纳入了 42 名 AN 患者和 42 名健康对照组。通过将 AN 患者按握力测试评分（高于/低于 22.5kg）分组，评估 BIA 预测 MS 的参数。
细胞膜电容（AUC=0.916）、200kHz 和 5kHz 阻抗比（AUC=0.924）、5kHz 相位角（PA）（AUC=0.906）和 50kHz PA（AUC=0.919）对区分 AN 患者和对照组的准确率最高。低 MS 组的 PA 50kHz（均值：4.03±0.80° vs. 4.58±0.65°；=0.032）和去脂体重指数（均值：12.22±1.41kg/m vs. 13.14±0.94kg/m；=0.026）明显较低。在单变量模型中，PA 50kHz≥4.037°与肌肉无力的可能性最低相关（OR=0.230；=0.005）。在多变量分析中，PA 50kHz 是 MS 的唯一显著因素（OR=0.01；=0.027）。
PA 50kHz 是预测 AN 患者 MS 的最佳 BIA 参数。它可能有助于在进行体力活动治疗前进行评估。
