静息态功能连接小脑前后叶在多发性硬化中发生改变。
Resting-state functional connectivity of anterior and posterior cerebellar lobes is altered in multiple sclerosis.
机构信息
Medicine and Health Science Department, University of Molise, Campobasso, Italy/Human Neuroscience Department, Sapienza University of Rome, Rome, Italy.
Human Neuroscience Department, Sapienza University of Rome, Rome, Italy.
出版信息
Mult Scler. 2021 Apr;27(4):539-548. doi: 10.1177/1352458520922770. Epub 2020 May 28.
BACKGROUND
Damage to the cerebellar sensorimotor and cognitive domains may underlie physical and cognitive disability.
OBJECTIVE
To investigate resting-state functional connectivity (FC) of sensorimotor and cognitive cerebellum, and clinical correlates in multiple sclerosis (MS).
METHODS
A total of 119 patients with MS and 42 healthy subjects underwent multimodal 3T-magnetic resonance imaging (MRI). Patients were evaluated using the Expanded Disability Status Scale and Multiple Sclerosis Functional Composite Scale. After parcellation of sensorimotor (lobules I-V + VIII) and cognitive cerebellum (lobules VI, VII, IX, X), we calculated cerebellar resting-state FC using a seed-based approach.
RESULTS
In patients with MS, the sensorimotor cerebellum showed increased FC mainly with cerebellar, thalamic, and cortical (frontal, parietal, temporal) areas and decreased FC with insular areas; the cognitive cerebellum showed increased FC mainly with thalamic and cortical (temporal-occipital) areas, and decreased FC with frontal-insular areas. Both sensorimotor and cognitive cerebellar FC negatively correlated with disability, and positively with cognitive scores. Cerebellar structural damage only partially influenced results.
CONCLUSION
The two neocerebellar circuits showed altered FC with subcortical and cortical areas. The association between increased sensorimotor and cognitive cerebellar FC and low levels of physical and cognitive disability suggests that altered FC might modulate the effects of cerebellar structural damage on clinical condition.
背景
小脑的感觉运动和认知领域的损伤可能是导致身体和认知障碍的原因。
目的
研究多发性硬化症（MS）患者小脑感觉运动和认知功能的静息态功能连接（FC）及其与临床的相关性。
方法
共纳入 119 例 MS 患者和 42 名健康对照者，进行多模态 3T 磁共振成像（MRI）检查。采用扩展残疾状况量表和多发性硬化功能综合量表对患者进行评估。对小脑感觉运动区（I-V 叶+VIII 叶）和认知区（VI、VII、IX、X 叶）进行分区后，采用种子点法计算小脑静息态 FC。
结果
在 MS 患者中，小脑感觉运动区 FC 增加，主要与小脑、丘脑和皮质（额、顶、颞）区相关，与脑岛区 FC 减少；小脑认知区 FC 增加，主要与丘脑和皮质（颞枕叶）区相关，与额岛区 FC 减少。小脑感觉运动和认知 FC 均与残疾呈负相关，与认知评分呈正相关。小脑结构损伤仅部分影响结果。
结论
这两个新小脑回路与皮质下和皮质区的 FC 发生改变。小脑感觉运动和认知 FC 增加与较低的身体和认知残疾程度相关，这表明 FC 的改变可能调节小脑结构损伤对临床状况的影响。
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