Program in Immunology, Stanford University School of Medicine, Stanford, CA, USA.
Program in Immunology, Stanford University School of Medicine, Stanford, CA, USA; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA; Chan Zuckerberg Biohub, San Francisco, CA, USA.
Cell Host Microbe. 2020 Jun 10;27(6):863-869. doi: 10.1016/j.chom.2020.05.009. Epub 2020 May 20.
The coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 has had devastating global impacts and will continue to have dramatic effects on public health for years to come. A better understanding of the immune response to SARS-CoV-2 will be critical for the application and development of therapeutics. The degree to which the innate immune response confers protection or induces pathogenesis through a dysregulated immune response remains unclear. In this review, we discuss what is known about the role of the innate immune system during SARS-CoV-2 infection, suggest directions for future studies, and evaluate proposed COVID-19 immunomodulating therapeutics.
由 SARS-CoV-2 引起的 2019 年冠状病毒病（COVID-19）大流行对全球造成了毁灭性的影响，并将在未来数年内继续对公共卫生产生巨大影响。更好地了解针对 SARS-CoV-2 的免疫反应对于治疗方法的应用和开发至关重要。先天免疫反应通过失调的免疫反应提供保护或诱导发病机制的程度尚不清楚。在这篇综述中，我们讨论了已知的先天免疫系统在 SARS-CoV-2 感染过程中的作用，提出了未来研究的方向，并评估了拟议的 COVID-19 免疫调节治疗方法。
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