Neuroscience Lab, Department of Cell Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Neuroscience Lab, Department of Cell Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Toxicon. 2020 Aug;183:44-50. doi: 10.1016/j.toxicon.2020.05.012. Epub 2020 May 26.
3-nitropropionic acid (3-NP) is a mycotoxin widely used to produce a rat model of Huntington's disease. While there are numerous studies on the effect of this neurotoxin, still further investigation is required to understand the influence of this toxin on different regions of the brain. In the present study, there are two groups of rats of which one is treated with 3-NP. Behavioral, stereological and immunohistochemical analyses were conducted. The results show that locomotor activity is largely affected and anxiety is induced up to a certain level, but there is no gross manifestation of deficit in memory. Microscopic observations illustrate damages in the hippocampus and other parts of the brain. Astrogliosis and glial scars were another finding of this study. In conclusion, although 3-NP can be used as a model of Huntington's disease, it exerts a disseminated effect on different regions of the brain.
3-硝基丙酸（3-NP）是一种广泛用于制备亨廷顿病大鼠模型的真菌毒素。虽然已有大量关于这种神经毒素影响的研究，但仍需要进一步研究以了解该毒素对大脑不同区域的影响。在本研究中，有两组大鼠，其中一组用 3-NP 处理。进行了行为学、体视学和免疫组织化学分析。结果表明，运动活动受到很大影响，焦虑被诱导到一定程度，但记忆没有明显缺陷的表现。显微镜观察表明海马体和大脑其他部位有损伤。星形胶质细胞增生和神经胶质瘢痕是本研究的另一个发现。总之，虽然 3-NP 可作为亨廷顿病的模型，但它对大脑的不同区域有弥散作用。
