Dansie Kathryn, Viecelli Andrea K, Pascoe Elaine M, Johnson David W, McDonald Stephen, Clayton Philip, Hawley Carmel
Australia and New Zealand Dialysis and Transplant Registry (ANZDATA), South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
Department of Nephrology, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia; Australasian Kidney Trials Network, University of Queensland, Brisbane, Queensland, Australia.
Kidney Int. 2020 Sep;98(3):572-578. doi: 10.1016/j.kint.2020.04.050. Epub 2020 May 25.
Randomized controlled trials (RCTs) are considered the gold standard for evaluating the effectiveness of interventions. However, criticisms of traditional designs are that they can be inefficient, inflexible, expensive, and conducted in a manner disconnected from real-life clinical practice. Novel strategies and approaches are being utilized to overcome these limitations, including comprehensive consumer engagement, core outcome sets, novel trial designs, streamlined data collection, cost-effectiveness and return on investment evaluations, knowledge dissemination plans, and impact evaluation. These strategies can be implemented at the design, conduct, implementation, and dissemination stages of the trial process. This review aims to provide an overview of these strategies and approaches to improve the relevance, efficiency, effectiveness, and impact of nephrology research.
随机对照试验（RCTs）被认为是评估干预措施有效性的金标准。然而，对传统设计的批评在于它们可能效率低下、缺乏灵活性、成本高昂，并且以与现实临床实践脱节的方式进行。正在采用新的策略和方法来克服这些局限性，包括全面的消费者参与、核心结局集、新型试验设计、简化的数据收集、成本效益和投资回报率评估、知识传播计划以及影响评估。这些策略可在试验过程的设计、实施、执行和传播阶段实施。本综述旨在概述这些策略和方法，以提高肾脏病学研究的相关性、效率、有效性和影响力。
