Moreno Andrea
Danish Institute of Translational Neuroscience (DANDRITE), Aarhus University, Aarhus C, Denmark.
Eur J Neurosci. 2021 Oct;54(8):6912-6932. doi: 10.1111/ejn.14839. Epub 2020 Jun 14.
The field of learning and memory has largely focused their efforts on memory formation, deeming the act of forgetting as a necessary and unavoidable error of the brain's storage system. However, recent studies show that forgetting might be a purposeful mechanism with dedicated molecular pathways. This has opened new avenues for the study of memory processes and their manipulation. This review article focuses on the proposed molecular pathways that could underlie forgetting (postsynaptic glutamate receptors and their subunit composition, structural proteins, kinases, phosphatases, and neuromodulators), and reviews the latest contributions to this topic. The discussed molecular pathways are then related to synaptic depotentiation, which is a proposed mechanism underlying forgetting.
学习与记忆领域主要将精力集中在记忆形成上，认为遗忘行为是大脑存储系统中必要且不可避免的错误。然而，最近的研究表明，遗忘可能是一种具有专门分子途径的有目的机制。这为记忆过程及其调控的研究开辟了新途径。这篇综述文章聚焦于可能构成遗忘基础的分子途径（突触后谷氨酸受体及其亚基组成、结构蛋白、激酶、磷酸酶和神经调质），并回顾了关于该主题的最新研究成果。随后将所讨论的分子途径与突触去增强作用联系起来，突触去增强作用是一种被提出的遗忘潜在机制。
