采用毛细管气相色谱法测定人血清中的氯氮平。
Determination of clozapine in human serum by capillary gas chromatography.
作者信息
Richter K
机构信息
Institut für Klinische Pharmakologie der Medizinischen Akademie Carl Gustav Carus, Dresden, G.D.R.
出版信息
J Chromatogr. 1988 Dec 30;434(2):465-8. doi: 10.1016/s0378-4347(88)80014-8.
PMID:3246536
Abstract
A gas chromatographic method using a fused-silica wide-bore capillary column and a nitrogen-specific detector for the determination of the antipsychotic agent clozapine in human serum is described. This method was found to be suitable for the determination of serum levels down to 1-2 ng/ml. The sensitivity, precision and accuracy of this method are adequate for studies on pharmacokinetics and bioavailability.
摘要
描述了一种使用熔融石英大口径毛细管柱和氮特异性检测器测定人血清中抗精神病药物氯氮平的气相色谱方法。该方法适用于测定低至1 - 2 ng/ml的血清水平。该方法的灵敏度、精密度和准确度足以用于药代动力学和生物利用度研究。
Zotero 插件