Vink J, van Hal H J
J Chromatogr. 1980 Jan 11;181(1):25-31. doi: 10.1016/s0378-4347(00)81265-7.
A simplified gas chromatographic method for determination of the antidepressant drug mianserin in human plasma is described. Application of a nitrogen-sensitive detector reduces the assay procedure to extraction, concentration and gas chromatographic determination. The method is suitable to determine mianserin in human plasma at the 1 ng/ml level on a routine basis. At the 20 ng/ml level the deviation of the mean from the true value and the relative standard deviation amount to 1.0% and 6.8%, respectively.
描述了一种用于测定人血浆中抗抑郁药物米安色林的简化气相色谱法。使用氮敏感检测器可将分析过程简化为萃取、浓缩和气相色谱测定。该方法适用于常规测定人血浆中浓度为1 ng/ml的米安色林。在20 ng/ml水平时，平均值与真实值的偏差以及相对标准偏差分别为1.0%和6.8%。
