Center for Immunology and Infectious Diseases, University of California Davis, Davis, CA 95616, USA.
Center for Immunology and Infectious Diseases, University of California Davis, Davis, CA 95616, USA.
Trends Immunol. 2020 Jul;41(7):614-628. doi: 10.1016/j.it.2020.05.001. Epub 2020 May 25.
Control of diverse pathogens requires an adaptive antibody response, dependent on cellular division of labor to allocate antigen-dependent B- and CD4 T-cell fates that collaborate to control the quantity and quality of antibody. This is orchestrated by the dynamic action of key transcriptional regulators mediating gene expression programs in response to pathogen-specific environmental inputs. We describe a conserved, likely ancient, gene regulatory network that intriguingly operates contemporaneously in B and CD4 T cells to control their cell fate dynamics and thus, the character of the antibody response. The remarkable output of this network derives from graded expression, designated by antigen receptor signal strength, of a pivotal transcription factor that regulates alternate cell fate choices.
控制多种病原体需要适应性抗体反应，这依赖于细胞分工，以分配依赖抗原的 B 细胞和 CD4 T 细胞命运，从而协同控制抗体的数量和质量。这是由关键转录调节因子的动态作用来协调的，这些转录因子介导基因表达程序，以响应病原体特异性的环境输入。我们描述了一个保守的、可能古老的基因调控网络，该网络在 B 和 CD4 T 细胞中同时运作，以控制它们的细胞命运动力学，从而控制抗体反应的特征。这个网络的显著输出源于关键转录因子的分级表达，该转录因子由抗原受体信号强度来指定，调节着替代的细胞命运选择。
