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Methotrexate reduces withdrawal rates of TNF inhibitors due to ineffectiveness in rheumatoid arthritis but only in patients who are seropositive.

作者信息

Greenwood Mandy, Shipa Muhammad, Yeoh Su-Ann, Roussou Euthalia, Mukerjee Dev, Ehrenstein Michael R

机构信息

Centre for Rheumatology, UCL, London, UK.

Rheumatology Department, Barking Havering and Redbridge University Hospitals NHS Trust, Romford, Essex, UK.

出版信息

Ann Rheum Dis. 2020 Nov;79(11):1516-1517. doi: 10.1136/annrheumdis-2020-217725. Epub 2020 May 28.

DOI:10.1136/annrheumdis-2020-217725
PMID:32467248
Abstract
摘要

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Tapering csDMARD or TNFi first: is the risk of flares different for ACPA-positive or ACPA-negative rheumatoid arthritis?首先逐渐减少传统合成改善病情抗风湿药(csDMARD)或肿瘤坏死因子抑制剂(TNFi):抗环瓜氨酸肽抗体(ACPA)阳性或阴性类风湿关节炎发作的风险是否不同?
RMD Open. 2024 Jul 20;10(3):e004258. doi: 10.1136/rmdopen-2024-004258.
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Antibodies (Basel). 2023 Oct 31;12(4):69. doi: 10.3390/antib12040069.
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The Genetic, Environmental, and Immunopathological Complexity of Autoantibody-Negative Rheumatoid Arthritis.自身抗体阴性类风湿关节炎的遗传、环境和免疫病理复杂性。
Int J Mol Sci. 2021 Nov 17;22(22):12386. doi: 10.3390/ijms222212386.
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Methotrexate Reduces the Probability of Discontinuation of TNF Inhibitors in Seropositive Patients With Rheumatoid Arthritis. A Real-World Data Analysis.甲氨蝶呤降低类风湿关节炎血清学阳性患者停用肿瘤坏死因子抑制剂的概率。一项真实世界数据分析。
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