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Tapering csDMARD or TNFi first: is the risk of flares different for ACPA-positive or ACPA-negative rheumatoid arthritis?

作者信息

Heutz Judith W, Looijen Agnes E M, van der Helm-van Mil Annette H M, de Jong Pascal H P, van Mulligen Elise

机构信息

Department of Rheumatology, Erasmus Medical Center, Rotterdam, Netherlands

Department of Rheumatology, Erasmus Medical Center, Rotterdam, Netherlands.

出版信息

RMD Open. 2024 Jul 20;10(3):e004258. doi: 10.1136/rmdopen-2024-004258.

DOI:10.1136/rmdopen-2024-004258
PMID:39032947
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11261664/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b999/11261664/3e2db545067b/rmdopen-10-3-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b999/11261664/3e2db545067b/rmdopen-10-3-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b999/11261664/3e2db545067b/rmdopen-10-3-g001.jpg

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本文引用的文献

1
Factors Associated With Maintenance of Remission Following Change From Combination Therapy to Monotherapy in Patients With Rheumatoid Arthritis.类风湿关节炎患者从联合治疗转换为单药治疗后病情缓解维持的相关因素
J Rheumatol. 2023 Sep;50(9):1114-1120. doi: 10.3899/jrheum.2022-1008. Epub 2023 Apr 15.
2
EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2022 update.EULAR 推荐的类风湿关节炎治疗方案：使用合成和生物疾病修正抗风湿药物：2022 更新版。
Ann Rheum Dis. 2023 Jan;82(1):3-18. doi: 10.1136/ard-2022-223356. Epub 2022 Nov 10.
3
Methotrexate prolongs TNF inhibitor survival, but only in autoantibody-positive rheumatoid arthritis: a validation study.
甲氨蝶呤可延长肿瘤坏死因子抑制剂的疗效，但仅在自身抗体阳性的类风湿性关节炎中有效：一项验证性研究。
Ann Rheum Dis. 2023 Oct;82(10):e217. doi: 10.1136/annrheumdis-2020-219499. Epub 2021 Jan 13.
4
Etanercept or Methotrexate Withdrawal in Rheumatoid Arthritis Patients in Sustained Remission.依那西普或甲氨蝶呤停药治疗持续缓解的类风湿关节炎患者。
Arthritis Rheumatol. 2021 May;73(5):759-768. doi: 10.1002/art.41589. Epub 2021 Mar 24.
5
Tapering towards DMARD-free remission in established rheumatoid arthritis: 2-year results of the TARA trial.在已确诊的类风湿关节炎中逐渐减少至无 DMARD 缓解：TARA 试验的 2 年结果。
Ann Rheum Dis. 2020 Sep;79(9):1174-1181. doi: 10.1136/annrheumdis-2020-217485. Epub 2020 Jun 1.
6
Methotrexate reduces withdrawal rates of TNF inhibitors due to ineffectiveness in rheumatoid arthritis but only in patients who are seropositive.甲氨蝶呤可降低类风湿关节炎患者中因肿瘤坏死因子抑制剂无效而导致的停药率，但仅在血清学阳性患者中有效。
Ann Rheum Dis. 2020 Nov;79(11):1516-1517. doi: 10.1136/annrheumdis-2020-217725. Epub 2020 May 28.
7
Prediction of disease relapses by multibiomarker disease activity and autoantibody status in patients with rheumatoid arthritis on tapering DMARD treatment.在逐渐减少改善病情抗风湿药（DMARD）治疗的类风湿关节炎患者中，通过多种生物标志物疾病活动度和自身抗体状态预测疾病复发
Ann Rheum Dis. 2016 Sep;75(9):1637-44. doi: 10.1136/annrheumdis-2015-207900. Epub 2015 Oct 19.
8
Relapse rates in patients with rheumatoid arthritis in stable remission tapering or stopping antirheumatic therapy: interim results from the prospective randomised controlled RETRO study.稳定缓解的类风湿关节炎患者在减少或停止抗风湿治疗时的复发率：前瞻性随机对照 RETRO 研究的中期结果。
Ann Rheum Dis. 2016 Jan;75(1):45-51. doi: 10.1136/annrheumdis-2014-206439. Epub 2015 Feb 6.
9
Developing a construct to evaluate flares in rheumatoid arthritis: a conceptual report of the OMERACT RA Flare Definition Working Group.开发评估类风湿关节炎 flares 的指标：OMERACT RA Flare Definition 工作组的概念报告。
J Rheumatol. 2011 Aug;38(8):1745-50. doi: 10.3899/jrheum.110400.