Mishima Y
Second Department of Surgery, Tokyo Medical and Dental University, Japan.
Jpn J Surg. 1988 Nov;18(6):615-9. doi: 10.1007/BF02471520.
Acute mesenteric ischemia is becoming an increasing cause of death in old patients with generalized atherosclerosis. Pathogenetically, this condition presents as poor splanchnic perfusion, with or without occlusion of the major visceral vessels. Because the patient manifests such nondescript abdominal pain and the physical examination reveals few abdominal signs, it is therefore extremely difficult to make an accurate diagnosis in the early stage of the disease. Furthermore, laboratory studies and X-ray examinations are usually noncontributory. It is therefore necessary to keep this lesion in mind, whenever examining the old patient with severe unexplained abdominal pain. Selective arteriography is essential for differentiating occlusive ischemia from non-occlusive, however, the recent advances in medical imaging and minute flowmetry make it possible to detect intestinal lesions and the state of visceral perfusion, transcutaneously, in the early stage of the disease. Emergency revascularization is mandatory for an occlusive lesion, but it is not indicated in the early stage of non-occlusive disease, and requires support of cardiac failure, hypovolemia, septic shock and lowered splanchnic perfusion.
急性肠系膜缺血正成为老年全身性动脉粥样硬化患者死亡的一个日益常见的原因。从发病机制来看,这种情况表现为内脏灌注不良,主要内脏血管有无闭塞均可出现。由于患者表现出如此难以描述的腹痛,而体格检查发现腹部体征很少,因此在疾病早期极难做出准确诊断。此外,实验室检查和X线检查通常并无帮助。因此,在检查患有严重不明原因腹痛的老年患者时,必须时刻牢记这种病变。选择性动脉造影对于区分闭塞性缺血和非闭塞性缺血至关重要,然而,医学成像和微量血流测定法的最新进展使得在疾病早期经皮检测肠道病变和内脏灌注状态成为可能。对于闭塞性病变,紧急血管重建是必需的,但在非闭塞性疾病的早期并不适用,并且需要应对心力衰竭、血容量不足、感染性休克和内脏灌注降低等情况。