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急性肠系膜缺血

Acute mesenteric ischemia.

作者信息

Mishima Y

机构信息

Second Department of Surgery, Tokyo Medical and Dental University, Japan.

出版信息

Jpn J Surg. 1988 Nov;18(6):615-9. doi: 10.1007/BF02471520.

DOI:10.1007/BF02471520
PMID:3246774
Abstract

Acute mesenteric ischemia is becoming an increasing cause of death in old patients with generalized atherosclerosis. Pathogenetically, this condition presents as poor splanchnic perfusion, with or without occlusion of the major visceral vessels. Because the patient manifests such nondescript abdominal pain and the physical examination reveals few abdominal signs, it is therefore extremely difficult to make an accurate diagnosis in the early stage of the disease. Furthermore, laboratory studies and X-ray examinations are usually noncontributory. It is therefore necessary to keep this lesion in mind, whenever examining the old patient with severe unexplained abdominal pain. Selective arteriography is essential for differentiating occlusive ischemia from non-occlusive, however, the recent advances in medical imaging and minute flowmetry make it possible to detect intestinal lesions and the state of visceral perfusion, transcutaneously, in the early stage of the disease. Emergency revascularization is mandatory for an occlusive lesion, but it is not indicated in the early stage of non-occlusive disease, and requires support of cardiac failure, hypovolemia, septic shock and lowered splanchnic perfusion.

摘要

急性肠系膜缺血正成为老年全身性动脉粥样硬化患者死亡的一个日益常见的原因。从发病机制来看,这种情况表现为内脏灌注不良,主要内脏血管有无闭塞均可出现。由于患者表现出如此难以描述的腹痛,而体格检查发现腹部体征很少,因此在疾病早期极难做出准确诊断。此外,实验室检查和X线检查通常并无帮助。因此,在检查患有严重不明原因腹痛的老年患者时,必须时刻牢记这种病变。选择性动脉造影对于区分闭塞性缺血和非闭塞性缺血至关重要,然而,医学成像和微量血流测定法的最新进展使得在疾病早期经皮检测肠道病变和内脏灌注状态成为可能。对于闭塞性病变,紧急血管重建是必需的,但在非闭塞性疾病的早期并不适用,并且需要应对心力衰竭、血容量不足、感染性休克和内脏灌注降低等情况。

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本文引用的文献

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Changes in serum total creatine phosphokinase (CPK) and its isoenzymes caused by experimental ligation of the superior mesenteric artery.实验性结扎肠系膜上动脉引起的血清总肌酸磷酸激酶(CPK)及其同工酶的变化。
Ann Surg. 1981 Apr;193(4):499-505.
2
A study of 136 patients with mesenteric infarction.一项针对136例肠系膜梗死患者的研究。
Surg Gynecol Obstet. 1967 Feb;124(2):251-61.
3
Treatment of mesenteric infarction.肠系膜梗死的治疗。
致命组合:军团病合并横纹肌溶解症、急性肾损伤和非闭塞性肠系膜缺血。
Am J Case Rep. 2023 Sep 24;24:e940792. doi: 10.12659/AJCR.940792.
4
Importance of intraoperative indocyanine green imaging in the management of non-occlusive mesenteric ischemia: a case report.术中吲哚菁绿成像在非闭塞性肠系膜缺血管理中的重要性:一例报告
Surg Case Rep. 2023 Feb 27;9(1):31. doi: 10.1186/s40792-023-01614-x.
5
A Case of Septicemia due to Nonocclusive Mesenteric Ischemia Occurring in Induction Chemotherapy.1例发生于诱导化疗期间的非闭塞性肠系膜缺血所致败血症
Case Rep Otolaryngol. 2018 Apr 19;2018:7426819. doi: 10.1155/2018/7426819. eCollection 2018.
6
ESTES guidelines: acute mesenteric ischaemia.埃斯蒂斯指南:急性肠系膜缺血
Eur J Trauma Emerg Surg. 2016 Apr;42(2):253-70. doi: 10.1007/s00068-016-0634-0.
7
Intestinal fatty acid binding protein is available for diagnosis of intestinal ischaemia: immunochemical analysis of two patients with ischaemic intestinal diseases.肠道脂肪酸结合蛋白可用于诊断肠道缺血:对两名缺血性肠道疾病患者的免疫化学分析
Gut. 1995 May;36(5):788-91. doi: 10.1136/gut.36.5.788.
Br J Surg. 1987 Jun;74(6):500-3. doi: 10.1002/bjs.1800740628.
4
In vivo noninvasive observation of acute mesenteric ischemia in rats.大鼠急性肠系膜缺血的体内无创观察
Surg Gynecol Obstet. 1987 May;164(5):409-14.
5
Mesenteric venous thrombosis--1911 to 1984.肠系膜静脉血栓形成——1911年至1984年
Surgery. 1987 Apr;101(4):383-8.
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Transcutaneous Doppler ultrasound measurement of superior mesenteric artery blood flow in man.人体肠系膜上动脉血流的经皮多普勒超声测量
Gut. 1986 Jan;27(1):100-5. doi: 10.1136/gut.27.1.100.
7
Transcutaneous Doppler ultrasound measurement of coeliac axis blood flow in man.
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