Kanda T, Fujii H, Fujita M, Sakai Y, Ono T, Hatakeyama K
Department of Surgery, Niigata University School of Medicine, Japan.
Gut. 1995 May;36(5):788-91. doi: 10.1136/gut.36.5.788.
Mesenteric infarction and other acute ischaemic intestinal diseases are still a challenging diagnostic problem. Based on animal experiments, intestinal fatty acid binding protein (I-FABP), which is uniquely localised to the bowel, has recently been proposed as a new serum marker for intestinal ischaemia. This paper reports on two cases with acute intestinal ischaemic diseases, and the measurement of serum I-FABP by western blot analysis. The concentrations of ordinary serum markers were normal and the bowel necrosis was not diagnosed until surgical exploration. Immunochemical analysis showed that the I-FABP concentrations in the patients' serum samples were high at the time of admission, and that I-FABP was undetectable in the samples obtained after bowel resection and in healthy control subjects. This paper suggests that I-FABP is released into the circulation in the acute phase of intestinal ischaemia and that I-FABP can be used in establishing the diagnosis of ischaemic intestinal diseases.
肠系膜梗死及其他急性缺血性肠道疾病仍然是一个具有挑战性的诊断难题。基于动物实验，肠道脂肪酸结合蛋白（I-FABP）仅在肠道中表达，最近被提议作为肠道缺血的一种新的血清标志物。本文报道了两例急性肠道缺血性疾病病例，并通过蛋白质免疫印迹分析测定了血清I-FABP。常规血清标志物浓度正常，直到手术探查才诊断出肠坏死。免疫化学分析表明，患者血清样本中I-FABP浓度在入院时较高，而在肠切除术后获得的样本以及健康对照者中未检测到I-FABP。本文表明，I-FABP在肠道缺血急性期释放入循环，并且I-FABP可用于缺血性肠道疾病的诊断。
