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使用定量磁共振成像评估的与椎体骨髓脂肪相关的椎间盘退变。

Intervertebral disc degeneration associated with vertebral marrow fat, assessed using quantitative magnetic resonance imaging.

作者信息

Ji Yayun, Hong Weifeng, Liu Mouyuan, Liang Yuying, Deng YongYan, Ma Liheng

机构信息

Department of Medical Imaging, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou City, 510080, Guangdong Province, China.

出版信息

Skeletal Radiol. 2020 Nov;49(11):1753-1763. doi: 10.1007/s00256-020-03419-7. Epub 2020 May 28.

DOI:10.1007/s00256-020-03419-7
PMID:32468097
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7497503/
Abstract

OBJECTIVE

To investigate the potential clinical application of quantitative MRI in assessing the correlation between lumbar vertebrae bone marrow fat deposition and intervertebral disc degeneration.

MATERIALS AND METHODS

A total of 104 chronic lower-back pain volunteers underwent 3.0-T MRI with T2-weighted imaging, T2 mapping, and iterative decomposition of water and fat with echo asymmetry and least squares estimation (IDEAL-IQ) between August 2018 and June 2019. Each disc was assessed with T2 value by T2 mapping, and the L1-S1 vertebral bone marrow fat fraction was assessed by IDEAL-IQ. The differences and relationship between T2 value and the adjacent vertebral bone marrow fat fraction values within the five Pfirrmann groups, five age groups, and five lumbar levels were statistically analyzed.

RESULTS

The vertebral bone marrow fat fraction had a significant negative correlation with T2 values of nucleus pulposus' T2 values (p < 0.001). However, the significant negative correlation was only found between T2 values of nucleus pulposus and adjacent vertebral bone marrow fat in Pfirrmann II-III, L1/2-L5/S1 level, and 40-49 years' age groups. Pfirrmann grades of the intervertebral disc were positively correlated with adjacent vertebrae bone marrow fat fraction (p < 0.05).

CONCLUSION

Lumbar bone marrow fat deposition significantly increases during the early stages of intervertebral disc degeneration. Quantitative measurements of bone marrow fat deposition and water content of intervertebral discs have a predictive value and are an important supplement to the qualitative traditional classification strategies for the early stages of intervertebral disc degeneration.

摘要

目的

探讨定量磁共振成像（MRI）在评估腰椎骨髓脂肪沉积与椎间盘退变相关性方面的潜在临床应用价值。

材料与方法

2018年8月至2019年6月期间，共有104名慢性下腰痛志愿者接受了3.0-T MRI检查，包括T2加权成像、T2图谱成像以及采用回波不对称最小二乘估算法（IDEAL-IQ）进行水脂迭代分解成像。通过T2图谱成像评估每个椎间盘的T2值，采用IDEAL-IQ评估L1-S1椎体骨髓脂肪分数。对五个Pfirrmann分级组、五个年龄组以及五个腰椎节段内的T2值与相邻椎体骨髓脂肪分数值之间的差异及关系进行统计学分析。

结果

椎体骨髓脂肪分数与髓核T2值呈显著负相关（p < 0.001）。然而，仅在Pfirrmann II-III级、L1/2-L5/S1节段以及40-49岁年龄组中发现髓核T2值与相邻椎体骨髓脂肪之间存在显著负相关。椎间盘的Pfirrmann分级与相邻椎体骨髓脂肪分数呈正相关（p < 0.05）。

结论

在椎间盘退变早期，腰椎骨髓脂肪沉积显著增加。定量测量骨髓脂肪沉积和椎间盘水分含量具有预测价值，是对椎间盘退变早期定性传统分类策略的重要补充。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b561/7497503/9d7dea323c35/256_2020_3419_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b561/7497503/ada60f540118/256_2020_3419_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b561/7497503/d26051d75c95/256_2020_3419_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b561/7497503/d33ec33df33d/256_2020_3419_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b561/7497503/ca6e39bc1feb/256_2020_3419_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b561/7497503/ccc783599c98/256_2020_3419_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b561/7497503/4552d08cb23a/256_2020_3419_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b561/7497503/560991ea89d3/256_2020_3419_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b561/7497503/56f8cfd60961/256_2020_3419_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b561/7497503/9d7dea323c35/256_2020_3419_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b561/7497503/ada60f540118/256_2020_3419_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b561/7497503/d26051d75c95/256_2020_3419_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b561/7497503/d33ec33df33d/256_2020_3419_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b561/7497503/ca6e39bc1feb/256_2020_3419_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b561/7497503/ccc783599c98/256_2020_3419_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b561/7497503/4552d08cb23a/256_2020_3419_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b561/7497503/560991ea89d3/256_2020_3419_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b561/7497503/56f8cfd60961/256_2020_3419_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b561/7497503/9d7dea323c35/256_2020_3419_Fig9_HTML.jpg

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