Department of Radiology, Honghui Hospital Affiliated Xi'an Jiaotong University, No. 555, Youyi East Road, Xi'an 710054, China.
Department of Spinal Surgery, Honghui Hospital Affiliated Xi'an Jiaotong University, No. 555, Youyi East Road, Xi'an 710054, China.
Eur Radiol. 2023 Sep;33(9):6001-6008. doi: 10.1007/s00330-023-09599-9. Epub 2023 Apr 5.
To investigate the correlation of R2* with vertebral fat fraction (FF) and bone mineral density (BMD), and to explore its role in the quantitative assessment of osteoporosis (OP).
A total of 83 patients with low back pain (59.77 ± 7.46 years, 30 males) were enrolled, which underwent lumbar MRI in IDEAL-IQ sequences and quantitative computed tomography (QCT) scanning within 48h. The FF, R2*, and BMD of all 415 lumbar vertebrae were respectively measured. According to BMD, all vertebrae were divided into BMD normal, osteopenia, and OP groups, and the difference of FF and R2* among groups was analyzed by one-way ANOVA. The correlation between R2*, FF, and BMD was analyzed by Pearson's test. Taking BMD as the gold standard, the efficacies for FF and R2* in diagnosis of OP and osteopenia were assessed by receiver operating characteristic curve, and their area under the curve (AUC) was compared with DeLong's test.
The FF and R2* were statistically different among groups (F values of 102.521 and 11.323, both p < 0.05), and R2* were significantly correlated with FF and BMD, respectively (r values of -0.219 and 0.290, both p < 0.05). In diagnosis of OP and osteopenia, the AUCs were 0.776 and 0.778 for FF and 0.638 and 0.560 for R2*, and the AUCs of R2* were lower than those of FF, with Z values of 4.030 and 4.087, both p < 0.001.
R2* is significantly correlated with FF and BMD and can be used as a complement to FF and BMD for quantitative assessment of OP.
• R2* based on IDEAL-IQ sequences has a definite but weak linear relationship with FF and BMD. • FF is significantly correlated with BMD and can effectively evaluate BMAT. • R2* can be used as a complement to FF and BMD for fine quantification of bone mineral loss and bone marrow fat conversion.
探讨 R2*与椎体脂肪分数（FF）和骨密度（BMD）的相关性，并探讨其在骨质疏松症（OP）定量评估中的作用。
共纳入 83 例腰痛患者（59.77±7.46 岁，男性 30 例），在 48h 内分别行腰椎 IDEAL-IQ 序列 MRI 和定量 CT（QCT）扫描。分别测量所有 415 个腰椎的 FF、R2和 BMD。根据 BMD，所有椎体均分为 BMD 正常、骨量减少和 OP 组，采用单因素方差分析比较组间 FF 和 R2的差异。采用 Pearson 检验分析 R2*、FF 与 BMD 的相关性。以 BMD 为金标准，采用受试者工作特征曲线（ROC 曲线）评估 FF 和 R2*诊断 OP 和骨量减少的效能，并采用 DeLong 检验比较其曲线下面积（AUC）。
组间 FF 和 R2差异有统计学意义（F 值分别为 102.521 和 11.323，均 P<0.05），R2与 FF 和 BMD 均呈显著负相关（r 值分别为-0.219 和 0.290，均 P<0.05）。在诊断 OP 和骨量减少时，FF 的 AUC 为 0.776 和 0.778，R2的 AUC 为 0.638 和 0.560，R2的 AUC 均低于 FF，Z 值分别为 4.030 和 4.087，均 P<0.001。
R2*与 FF 和 BMD 显著相关，可作为 FF 和 BMD 的补充，用于 OP 的定量评估。
基于 IDEAL-IQ 序列的 R2*与 FF 和 BMD 具有明确但较弱的线性关系。
FF 与 BMD 显著相关，可有效评估骨髓脂肪含量。
R2*可作为 FF 和 BMD 的补充，用于精细定量评估骨矿物质丢失和骨髓脂肪转化。
