Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA.
Department of Public Health, College of Health and Human Sciences, Purdue University, West Lafayette, Indiana, USA.
J Vet Intern Med. 2020 Jul;34(4):1642-1649. doi: 10.1111/jvim.15813. Epub 2020 May 29.
Optical neuronavigation-guided intracranial surgery has become increasingly common in veterinary medicine, but its use has not yet been described in horses.
To determine the feasibility of optical neuronavigation-guided intracranial biopsy procedures in the horse, compare the use of the standard fiducial array and anatomic landmarks for patient registration, and evaluate surgeon experience.
Six equine cadaver heads.
Computed tomography images of each specimen were acquired, with the fiducial array rigidly secured to the frontal bone. Six targets were selected in each specimen. Patient registration was performed separately for 3 targets using the fiducial array, and for 3 targets using anatomic landmarks. In lieu of biopsy, 1 mm diameter wire seeds were placed at each target. Postoperative images were coregistered with the planning scan to calculate Euclidian distance from the tip of the seed to the target.
No statistical difference between registration techniques was identified. The impact of surgeon experience was examined for each technique using a Mann-Whitney U test. The experienced surgeon was significantly closer to the intended target (median = 2.52 mm) than were the novice surgeons (median = 6.55 mm) using the fiducial array (P = .001). Although not statistically significant (P = .31), for the experienced surgeon the median distance to target was similar when registering with the fiducial array (2.47 mm) and anatomic landmarks (2.58 mm).
Registration using both fiducial arrays and anatomic landmarks for brain biopsy using optical neuronavigation in horses is feasible.
光学神经导航引导下的颅内手术在兽医领域已越来越普遍，但在马中尚未见相关报道。
确定在马中进行光学神经导航引导下颅内活检的可行性，比较使用标准基准标记和解剖学标志进行患者配准的效果，并评估外科医生的经验。
6 个马头颅标本。
对每个标本的计算机断层扫描图像进行采集，将基准标记刚性固定于额骨。在每个标本中选择 6 个目标。使用基准标记分别对 3 个目标进行患者配准，使用解剖学标志对 3 个目标进行患者配准。活检替代物为每个目标处放置 1 mm 直径的金属丝种子。将术后图像与计划扫描进行配准，以计算种子尖端到目标的欧几里得距离。
未发现两种注册技术之间存在统计学差异。使用 Mann-Whitney U 检验检查了每种技术的外科医生经验的影响。与新手外科医生相比（中位数=6.55 mm），经验丰富的外科医生使用基准标记（中位数=2.52 mm）时更接近目标（P=.001）。尽管没有统计学意义（P=.31），但对于经验丰富的外科医生，使用基准标记（中位数=2.47 mm）和解剖学标志（中位数=2.58 mm）注册时，目标的中位数距离相似。
在马中使用光学神经导航进行脑活检时，使用基准标记和解剖学标志进行注册是可行的。
