The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA; Department of Surgery, Division of Surgical Oncology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA; Department of Surgery, Division of Surgical Oncology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Cancer Lett. 2020 Sep 1;487:27-33. doi: 10.1016/j.canlet.2020.04.026. Epub 2020 May 26.
Liposarcoma (LPS) is the most prevalent soft tissue sarcoma; among the four different LPS subtypes, dedifferentiated liposarcoma (DDLPS) is especially worrisome given its propensity for local and distant recurrence, with an overall survival rate of only 10% at 10 years. Our understanding of the molecular drivers of this disease is rudimentary at best; knowledge about how DDLPS interacts with cells in the tumor microenvironment (TME) is also lacking. Extracellular vesicle (EVs) have been studied in a number of different systems concerning their ability to influence the TME transferring bioactive molecules. In this review, we outline the role of the TME in the DDLPS progression and recurrence, focusing on the interplay between EVs released from the tumor and their target recipient cells in the TME. Success in the understanding of this process will be critical to an enhanced understanding of the underlying biologic drivers at play, potentially leading to new therapeutic strategies of benefit to patients with this disease.
脂肪肉瘤（LPS）是最常见的软组织肉瘤；在四种不同的 LPS 亚型中，去分化脂肪肉瘤（DDLPS）尤其令人担忧，因为它具有局部和远处复发的倾向，其 10 年总生存率仅为 10%。我们对这种疾病的分子驱动因素的了解充其量只是初步的；对 DDLPS 如何与肿瘤微环境（TME）中的细胞相互作用的了解也很缺乏。已经在许多不同的系统中研究了细胞外囊泡（EVs），以研究其影响 TME 传递生物活性分子的能力。在这篇综述中，我们概述了 TME 在 DDLPS 进展和复发中的作用，重点介绍了肿瘤释放的 EVs 与其在 TME 中的靶受体细胞之间的相互作用。成功理解这一过程对于增强对发挥作用的潜在生物学驱动因素的理解至关重要，这可能为患有这种疾病的患者带来新的治疗策略。
