Adib Anita, Sahu Ruhi, Mohta Shivangi, Pollock Raphael Etomar, Casadei Lucia
The James Cancer Hospital Solove Research Institute, The Ohio State University, Columbus, OH 43210, USA.
Division of Surgical Oncology, Department of Surgery, The Ohio State University, Columbus, OH 43210, USA.
Life (Basel). 2022 Mar 26;12(4):481. doi: 10.3390/life12040481.
Soft tissue sarcomas (STS) are rare malignancies with limited responses to anticancer therapy. Extracellular vesicles (EVs) are a heterogeneous group of bi-lipid layer sacs secreted by cells into extracellular space. Investigations of tumor-derived EVs have revealed their functional capabilities, including cell-to-cell communication and their impact on tumorigenesis, progression, and metastasis; however information on the roles of EVs in sarcoma is currently limited. In this review we investigate the role of various EV cargos in sarcoma and the mechanisms by which those cargos can affect the recipient cell phenotype and the aggressivity of the tumor itself. The study of EVs in sarcoma may help establish novel therapeutic approaches that target specific sarcoma subtypes or biologies, thereby improving sarcoma therapeutics in the future.
软组织肉瘤（STS）是一种罕见的恶性肿瘤，对抗癌治疗的反应有限。细胞外囊泡（EVs）是细胞分泌到细胞外空间的一组异质性双脂层囊泡。对肿瘤来源的细胞外囊泡的研究揭示了它们的功能，包括细胞间通讯以及它们对肿瘤发生、进展和转移的影响；然而，目前关于细胞外囊泡在肉瘤中的作用的信息有限。在这篇综述中，我们研究了各种细胞外囊泡货物在肉瘤中的作用，以及这些货物影响受体细胞表型和肿瘤本身侵袭性的机制。对肉瘤中细胞外囊泡的研究可能有助于建立针对特定肉瘤亚型或生物学特性的新型治疗方法，从而在未来改善肉瘤治疗。
