血浆高迁移率族蛋白 B1 与可溶性晚期糖基化终产物受体的关系与脑出血的临床转归。
The association between plasma HMGB1 and sRAGE and clinical outcome in intracerebral hemorrhage.
机构信息
Department of Neurology, First Affiliated Hospital of Kunming Medical University, Yunnan Province, PR China.
Department of Neurology, First Affiliated Hospital of Kunming Medical University, Yunnan Province, PR China.
出版信息
J Neuroimmunol. 2020 Aug 15;345:577266. doi: 10.1016/j.jneuroim.2020.577266. Epub 2020 May 22.
High-mobility group box 1 (HMGB1) and advanced glycation end-products (RAGE) are potential mediators of inflammation. We investigate the association between levels of HMGB1 and soluble RAGE (sRAGE) following intracerebral hemorrhage (ICH) and the severity of ICH. There was a significant trend towards higher poor functional outcome rate with increasing HMGB1 and sRAGE tercile. The correlation analysis indicated that the levels of HMGB1and sRAGE were positively correlated with hematoma volume. The receiver operating curve (ROC) was 0.718 for HMGB1 and 0.631 for sRAGE to poor functional outcome. HMGB1 and sRAGE quantification provides more accurate prognostic information after ICH.
高迁移率族蛋白 B1（HMGB1）和晚期糖基化终产物（RAGE）是炎症的潜在介质。我们研究了脑出血（ICH）后 HMGB1 和可溶性 RAGE（sRAGE）水平与 ICH 严重程度之间的关系。随着 HMGB1 和 sRAGE 三分位数的增加，不良功能结局的发生率呈显著上升趋势。相关性分析表明，HMGB1 和 sRAGE 的水平与血肿体积呈正相关。HMGB1 的 ROC 曲线为 0.718，sRAGE 的 ROC 曲线为 0.631，均提示对不良功能结局的预测价值。HMGB1 和 sRAGE 的定量检测可为 ICH 后提供更准确的预后信息。
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