Yao Jiayong, Dai Xiaohong, Yv Xueping, Zheng Lei, Zheng Jia, Kuang Binglin, Teng Wei, Yu Weiwei, Li Mingyue, Cao Hongtao, Zou Wei
First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China.
Key Laboratory of Clinical Molecular Biology of Integrated Traditional Chinese and Western Medicine in Heilongjiang Province, Harbin, Heilongjiang, China.
Front Mol Biosci. 2025 Feb 4;12:1541230. doi: 10.3389/fmolb.2025.1541230. eCollection 2025.
Intracerebral hemorrhage (ICH) is a non traumatic hemorrhage that occurs in a certain part of the brain. It usually leads to brain cell damage. According to a large number of experimental research, oxidative stress is an important pathophysiological processes of cerebral hemorrhage. In this paper, we aim to determine how changes in oxidative stress biomarkers indicate the damage degree of cerebral hemorrhage, and to explore and summarize potential treatments or interventions. We found that patients with cerebral hemorrhage are characterized by increased levels of oxidative stress markers, such as total malondialdehyde (MDA), F2 isoprostaglandin, hydroxynonenal, myeloperoxidase and protein hydroxyl. Therefore, the changes of oxidative stress caused by ICH on these markers can be used to evaluate and diagnose ICH, predict its prognosis, and guide preventive treatment to turn to antioxidant based treatment as a new treatment alternative.
脑出血（ICH）是一种发生在大脑特定部位的非创伤性出血。它通常会导致脑细胞损伤。根据大量的实验研究，氧化应激是脑出血重要的病理生理过程。在本文中，我们旨在确定氧化应激生物标志物的变化如何表明脑出血的损伤程度，并探索和总结潜在的治疗方法或干预措施。我们发现，脑出血患者的特点是氧化应激标志物水平升高，如总丙二醛（MDA）、F2异前列腺素、羟基壬烯醛、髓过氧化物酶和蛋白质羟基。因此，ICH引起的氧化应激对这些标志物的变化可用于评估和诊断ICH，预测其预后，并指导预防性治疗转向以抗氧化剂为基础的治疗作为一种新的治疗选择。
