Schepens Eye Research Institute, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, 02114, USA; Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan; Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan.
Schepens Eye Research Institute, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, 02114, USA.
Ocul Surf. 2021 Jan;19:157-168. doi: 10.1016/j.jtos.2020.05.009. Epub 2020 May 26.
Th17 cells have been implicated in the pathogenesis of numerous inflammatory and autoimmune conditions. At the ocular surface, Th17 cells have been identified as key effector cells in chronic ocular surface disease. Evidence from murine studies indicates that following differentiation and expansion, Th17 cells migrate from the lymphoid tissues to the eye, where they release inflammatory cytokines including, but not limited to, their hallmark cytokine IL-17A. As the acute phase subsides, a population of long-lived memory Th17 cells persist, which predispose hosts both to chronic inflammation and severe exacerbations of disease; of great interest is the small subset of Th17/1 cells that secrete both IL-17A and IFN-γ in acute-on-chronic disease exacerbation. Over the past decade, substantial progress has been made in deciphering how Th17 cells interact with the immune and neuroimmune pathways that mediate chronic ocular surface disease. Here, we review (i) the evidence for Th17 immunity in chronic ocular surface disease, (ii) regulatory mechanisms that constrain the Th17 immune response, and (iii) novel therapeutic strategies targeting Th17 cells.
Th17 细胞被认为与许多炎症和自身免疫性疾病的发病机制有关。在眼表面，Th17 细胞已被确定为慢性眼表面疾病的关键效应细胞。来自小鼠研究的证据表明，在分化和扩增后，Th17 细胞从淋巴组织迁移到眼睛，在那里它们释放炎症细胞因子，包括但不限于其标志性细胞因子 IL-17A。随着急性期的消退，一群长寿的记忆性 Th17 细胞持续存在，这使宿主既容易发生慢性炎症，又容易发生疾病的严重恶化；非常有趣的是，在急性加重慢性疾病中，一小部分 Th17/1 细胞同时分泌 IL-17A 和 IFN-γ。在过去的十年中，人们在破译 Th17 细胞如何与介导慢性眼表面疾病的免疫和神经免疫途径相互作用方面取得了重大进展。在这里，我们回顾了（i）Th17 免疫在慢性眼表面疾病中的证据，（ii）限制 Th17 免疫反应的调节机制，以及（iii）针对 Th17 细胞的新型治疗策略。
