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色素上皮衍生因子（PEDF）在癌症中的多种作用。

The Various Roles of PEDF in Cancer.

作者信息

Elmi Mitra, Dass Joshua H, Dass Crispin R

机构信息

Curtin Medical School, Curtin University, Bentley, WA 6102, Australia.

Curtin Health Innovation Research Institute, Curtin Medical School, Curtin University, Bentley, WA 6102, Australia.

出版信息

Cancers (Basel). 2024 Jan 24;16(3):510. doi: 10.3390/cancers16030510.

DOI:10.3390/cancers16030510
PMID:38339261
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10854708/
Abstract

Pigment epithelium-derived factor (PEDF) is a natural immunomodulator, anti-inflammatory, anti-angiogenic, anti-tumour growth and anti-metastasis factor, which can enhance tumour response to PEDF but can also conversely have pro-cancerous effects. Inflammation is a major cause of cancer, and it has been proven that PEDF has anti-inflammatory properties. PEDF's functional activity can be investigated through measuring metastatic and metabolic biomarkers that will be discussed in this review.

摘要

色素上皮衍生因子（PEDF）是一种天然免疫调节剂、抗炎、抗血管生成、抗肿瘤生长和抗转移因子，它既能增强肿瘤对PEDF的反应，也可能反之具有促癌作用。炎症是癌症的主要病因，且已证实PEDF具有抗炎特性。PEDF的功能活性可通过测量转移性和代谢生物标志物来研究，本文将对此进行讨论。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b135/10854708/10f264ad6de5/cancers-16-00510-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b135/10854708/18b68c40da0a/cancers-16-00510-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b135/10854708/10f264ad6de5/cancers-16-00510-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b135/10854708/18b68c40da0a/cancers-16-00510-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b135/10854708/10f264ad6de5/cancers-16-00510-g002.jpg

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Biomedicines. 2024 Oct 4;12(10):2260. doi: 10.3390/biomedicines12102260.
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