色素上皮衍生因子（PEDF）在癌症中的多种作用。
The Various Roles of PEDF in Cancer.
作者信息
Elmi Mitra, Dass Joshua H, Dass Crispin R
机构信息
Curtin Medical School, Curtin University, Bentley, WA 6102, Australia.
Curtin Health Innovation Research Institute, Curtin Medical School, Curtin University, Bentley, WA 6102, Australia.
出版信息
Cancers (Basel). 2024 Jan 24;16(3):510. doi: 10.3390/cancers16030510.
Pigment epithelium-derived factor (PEDF) is a natural immunomodulator, anti-inflammatory, anti-angiogenic, anti-tumour growth and anti-metastasis factor, which can enhance tumour response to PEDF but can also conversely have pro-cancerous effects. Inflammation is a major cause of cancer, and it has been proven that PEDF has anti-inflammatory properties. PEDF's functional activity can be investigated through measuring metastatic and metabolic biomarkers that will be discussed in this review.
色素上皮衍生因子（PEDF）是一种天然免疫调节剂、抗炎、抗血管生成、抗肿瘤生长和抗转移因子，它既能增强肿瘤对PEDF的反应，也可能反之具有促癌作用。炎症是癌症的主要病因，且已证实PEDF具有抗炎特性。PEDF的功能活性可通过测量转移性和代谢生物标志物来研究，本文将对此进行讨论。
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