School of Pharmacy, Jiangsu University, Zhenjiang 212013, China; Department of Traditional Chinese Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang 212013, China.
Hepatic Disease Institute, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan 430061, China; Hubei Provincial Academy of Traditional Chinese Medicine, Wuhan 430074, China.
Food Chem. 2020 Oct 15;327:127093. doi: 10.1016/j.foodchem.2020.127093. Epub 2020 May 18.
The development of functional foods based on medicinal food ingredients has become a hot topic in China. Di Wu Yang Gan (DWYG) is a Chinese medicinal food that contains five dietary plants. Various health benefits, including anti-inflammation, liver regeneration regulation, have been reported, though the mechanism is not clear. This study aimed to investigate the protective effect of DWYG on carbon tetrachloride-induced acute liver injury (ALI) in embryonic liver L-02 cells and mice model. DWYG-medicated serum protected L-02 cells from carbon tetrachloride-induced damage, reduced the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in the culture medium, decreased the expression of Bax and increased the expression of Bcl-2. Mice study suggested that DWYG decreased the levels of malondialdehyde, ALT and AST. Together, these results suggest the hepatoprotective effects of DWYG against ALI and provide an experimental basis for the utilization of DWYG to treat liver damage.
基于药食同源成分的功能性食品的开发已成为中国的一个热门话题。当归生姜羊肉汤是一种含五种食用植物的药食同源食品。据报道，它具有多种健康益处，包括抗炎、肝再生调节等，但具体机制尚不清楚。本研究旨在探讨当归生姜羊肉汤对四氯化碳诱导的胚胎肝 L-02 细胞急性肝损伤（ALI）及小鼠模型的保护作用。当归生姜羊肉汤含药血清可保护 L-02 细胞免受四氯化碳损伤，降低细胞培养液中丙氨酸转氨酶（ALT）和天冬氨酸转氨酶（AST）的水平，降低 Bax 的表达，增加 Bcl-2 的表达。小鼠研究表明，当归生姜羊肉汤降低了丙二醛、ALT 和 AST 的水平。综上所述，这些结果提示当归生姜羊肉汤对 ALI 具有肝保护作用，为其治疗肝损伤提供了实验依据。
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