Departamento de Neurociencia Cognitiva, División Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad de México 04510, Mexico.
Departamento de Biología Molecular e Histocompatibilidad, Hospital General Dr. Manuel Gea González, Secretaría de Salud, Ciudad de México 14080, Mexico.
Int J Mol Sci. 2020 May 27;21(11):3819. doi: 10.3390/ijms21113819.
Transient receptor potential (TRP) channels are remarkable transmembrane protein complexes that are essential for the physiology of the tissues in which they are expressed. They function as non-selective cation channels allowing for the signal transduction of several chemical, physical and thermal stimuli and modifying cell function. These channels play pivotal roles in the nervous and reproductive systems, kidney, pancreas, lung, bone, intestine, among others. TRP channels are finely modulated by different mechanisms: regulation of their function and/or by control of their expression or cellular/subcellular localization. These mechanisms are subject to being affected by several endogenously-produced compounds, some of which are of a lipidic nature such as steroids. Fascinatingly, steroids and TRP channels closely interplay to modulate several physiological events. Certain TRP channels are affected by the typical genomic long-term effects of steroids but others are also targets for non-genomic actions of some steroids that act as direct ligands of these receptors, as will be reviewed here.
瞬时受体电位 (TRP) 通道是一种卓越的跨膜蛋白复合物，对于其表达的组织的生理学至关重要。它们作为非选择性阳离子通道发挥作用，允许多种化学、物理和热刺激的信号转导，并修饰细胞功能。这些通道在神经系统和生殖系统、肾脏、胰腺、肺、骨骼、肠道等中发挥关键作用。TRP 通道通过不同的机制进行精细调节：调节其功能和/或通过控制其表达或细胞/亚细胞定位来调节其功能。这些机制受到许多内源性产生的化合物的影响，其中一些是脂类化合物，如类固醇。有趣的是，类固醇和 TRP 通道密切相互作用，以调节几种生理事件。某些 TRP 通道受到类固醇典型的基因组长期作用的影响，但其他 TRP 通道也是某些类固醇的非基因组作用的靶标，这些类固醇作为这些受体的直接配体发挥作用，如下所述。
