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CCL2/CCR2 信号在癌症发病机制中的作用。

CCL2/CCR2 signaling in cancer pathogenesis.

机构信息

Division of Cancer Research and Training, Charles R. Drew University of Medicine and Science, Los Angeles, CA, 90059, USA.

David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA.

出版信息

Cell Commun Signal. 2020 May 29;18(1):82. doi: 10.1186/s12964-020-00589-8.

DOI:10.1186/s12964-020-00589-8
PMID:32471499
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7257158/
Abstract

Chemokines are a family of small cytokines, which guide a variety of immune/inflammatory cells to the site of tumor in tumorigenesis. A dysregulated expression of chemokines is implicated in different types of cancer including prostate cancer. The progression and metastasis of prostate cancer involve a complex network of chemokines that regulate the recruitment and trafficking of immune cells. The chemokine CCL2 and its main receptor CCR2 have been receiving particular interest on their roles in cancer pathogenesis. The up-regulation of CCL2/CCR2 and varied immune conditions in prostate cancer, are associated with cancer advancement, metastasis, and relapse. Here we reviewed recent findings, which link CCL2/CCR2 to the inflammation and cancer pathogenesis, and discussed the therapeutic potential of CCL2/CCR2 axis in cancer treatment based on results from our group and other investigators, with a major focus on prostate cancer. Video Abstract.

摘要

趋化因子是一类小分子细胞因子，可引导多种免疫/炎症细胞向肿瘤发生部位迁移。趋化因子表达失调与多种癌症有关，包括前列腺癌。前列腺癌的进展和转移涉及调节免疫细胞募集和迁移的趋化因子的复杂网络。趋化因子 CCL2 及其主要受体 CCR2 在癌症发病机制中的作用受到特别关注。CCL2/CCR2 的上调和前列腺癌中的各种免疫状态与癌症进展、转移和复发有关。在这里，我们综述了最近的研究结果，这些结果将 CCL2/CCR2 与炎症和癌症发病机制联系起来，并根据我们小组和其他研究人员的结果讨论了 CCL2/CCR2 轴在癌症治疗中的治疗潜力，主要集中在前列腺癌上。视频摘要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/525e/7257158/c3859635f80c/12964_2020_589_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/525e/7257158/2bfd25f4aef6/12964_2020_589_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/525e/7257158/98307eb26ca1/12964_2020_589_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/525e/7257158/52ce0ffa0869/12964_2020_589_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/525e/7257158/5f8c2e33a290/12964_2020_589_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/525e/7257158/c3859635f80c/12964_2020_589_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/525e/7257158/2bfd25f4aef6/12964_2020_589_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/525e/7257158/98307eb26ca1/12964_2020_589_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/525e/7257158/52ce0ffa0869/12964_2020_589_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/525e/7257158/5f8c2e33a290/12964_2020_589_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/525e/7257158/c3859635f80c/12964_2020_589_Fig5_HTML.jpg

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CCL2/CCR2 signaling in cancer pathogenesis.

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引用本文的文献

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Pharmacological inhibition of the CCL2-CCR2 axis fails to reduce inflammation in a rat model of acute lung injury.

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[2]
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NPJ Breast Cancer. 2025-8-26

[3]
Caloric restriction protects from acute and chronic kidney injury by inhibiting monocyte recruitment.

iScience. 2025-7-11

[4]
Azelaic acid attenuates CCL2/CCR2 axis-mediated skin trafficking of acute myeloid leukemia cells through NF-κB/MAPK signaling modulation in keratinocytes.

BMC Cancer. 2025-7-31

[5]
The inhibitory effects of 7ND protein on osteoclast differentiation in apical periodontitis.

Front Cell Infect Microbiol. 2025-6-27

[6]
Macrophages foster anti-tumor immunity by ZEB1-dependent cytotoxic T cell chemoattraction.

Commun Biol. 2025-7-1

[7]
Evidence for a JAK2/STAT3 proinflammatory and vasculogenic mimicry interrelated molecular signature in adipocyte-derived mesenchymal stromal/stem cells.

Cell Commun Signal. 2025-6-19

[8]
Human cytomegalovirus UL23 inhibits immune cell migration and blocks antiviral immune cell responses by reducing the expression of chemokines CCL2 and CCL5.

Virulence. 2025-12

[9]
CCR2 overexpressing gingiva mesenchymal stem cells provide high intestinal regeneration in a rat model of ulcerative colitis.

PLoS One. 2025-6-5

[10]
Dual inhibition of oxidative phosphorylation and glycolysis using a hyaluronic acid nanoparticle NOX inhibitor enhanced response to radiotherapy in colorectal cancer.

Biomaterials. 2025-12

本文引用的文献

[1]
Arctigenin inhibits prostate tumor growth in high-fat diet fed mice through dual actions on adipose tissue and tumor.

Sci Rep. 2020-1-29

[2]
Prostate Cancer: The Role of Inflammation and Chemokines.

Am J Pathol. 2019-8-14

[3]
The Impact of the Adipose Organ Plasticity on Inflammation and Cancer Progression.

Cells. 2019-6-30

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Obesity, Inflammation, and Prostate Cancer.

J Clin Med. 2019-2-6

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Adipogenesis and metabolic health.

Nat Rev Mol Cell Biol. 2019-4

[6]
Periprostatic Adipose Tissue Favors Prostate Cancer Cell Invasion in an Obesity-Dependent Manner: Role of Oxidative Stress.

Mol Cancer Res. 2019-1-3

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Immunosuppression mediated by myeloid-derived suppressor cells (MDSCs) during tumour progression.

Br J Cancer. 2018-11-9

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Monocytes in rheumatoid arthritis: Circulating precursors of macrophages and osteoclasts and, their heterogeneity and plasticity role in RA pathogenesis.

Int Immunopharmacol. 2018-10-23

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Obesity, risk of biochemical recurrence, and prostate-specific antigen doubling time after radical prostatectomy: results from the SEARCH database.

BJU Int. 2018-11-16

[10]
Bipolar Tumor-Associated Macrophages in Ovarian Cancer as Targets for Therapy.

Cancers (Basel). 2018-9-29

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