青少年 1 型糖尿病患者的急性高血糖与空间工作记忆。
Acute Hyperglycemia and Spatial Working Memory in Adolescents With Type 1 Diabetes.
机构信息
UMC-University Children's Hospital Ljubljana, Ljubljana, Slovenia.
Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
出版信息
Diabetes Care. 2020 Aug;43(8):1941-1944. doi: 10.2337/dc20-0171. Epub 2020 May 29.
OBJECTIVE
To investigate the effect of acute hyperglycemia on brain function in adolescents with type 1 diabetes (T1D).
RESEARCH DESIGN AND METHODS
Twenty participants with T1D (aged 14.64 ± 1.78 years) and 20 age-matched healthy control subjects (aged 14.40 ± 2.82 years) performed two functional MRI sessions. Participants with T1D performed the first scanning session under euglycemic and the second under hyperglycemic clamp (20 mmol/L [360 mg/dL]).
RESULTS
Lower spatial working memory (sWM) capacity during acute hyperglycemia and significant differences in activation of regions of interest during different stages of the sWM task ( = 0.014) were observed.
CONCLUSIONS
Acute hyperglycemia negatively affected sWM capacity in adolescents with T1D, which is relevant for daily functioning and academic performance.
目的
研究急性高血糖对 1 型糖尿病（T1D）青少年脑功能的影响。
研究设计和方法
20 名 T1D 参与者（年龄 14.64 ± 1.78 岁）和 20 名年龄匹配的健康对照者（年龄 14.40 ± 2.82 岁）进行了两次功能磁共振成像（fMRI）扫描。T1D 参与者在正常血糖和高血糖钳夹（20 mmol/L [360 mg/dL]）下进行了第一次扫描。
结果
在急性高血糖期间，空间工作记忆（sWM）能力降低，在 sWM 任务的不同阶段，感兴趣区域的激活存在显著差异（ = 0.014）。
结论
急性高血糖对 T1D 青少年的 sWM 能力产生负面影响，这与日常功能和学业表现相关。
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