Department of Oral & Maxillofacial Plastic Surgery, University Hospital Bonn, Venusberg Campus 1, Haus 11, 2. OG, D-53127, Bonn, Germany.
Clin Oral Investig. 2021 Jan;25(1):187-193. doi: 10.1007/s00784-020-03350-0. Epub 2020 May 29.
The aim of this study was categorizing the microbial flora and susceptibility to antibiotics and to clarify to which degree the empiric administered antibiotics are suitable for therapy.
A 3.5-year retrospective study evaluated hospital records of 206 patients who suffered from head and neck infections of odontogenic origin. All patients underwent surgical incision and drainage and received intravenous antibiotics and inpatient treatment. The specimens were obtained by performing a swab.
Two hundred six patients were included with 251 strains isolated (1.22 per patient). One hundred eight strains showed antibiotic resistance. Eighty-seven patients showed at least one bacterial strain that showed antibiotic resistance (42.2%). The most frequent isolated bacteria were Streptococcus spp. (n = 116), with a high rate of antibiotic resistance (50.8%). We investigated 205 cases of antibiotic resistance in 87 subjects. Nine bacterial strains showed no susceptibility to unacid (4.3%) and 36 strains to clindamycin (17.5%).
Antibiotic resistance against clindamycin was rather high. The distribution of the afflicted spaces and isolated bacteria was alike recent findings. It is mandatory to understand that immediate surgical treatment in terms of incision and drainage is the basis in abscess treatment. Antibiotic treatment is adjunct therapy.
Streptococcus species were the most frequently identified bacteria presenting antibiotic resistance in more than 50%. Increased resistant rates for clindamycin require reconsiderations regarding an empiric antibiotic treatment.
本研究旨在对微生物菌群进行分类，并确定抗生素的敏感性，明确经验性应用的抗生素在多大程度上适合治疗。
一项为期 3.5 年的回顾性研究评估了 206 例因牙源性来源的头颈部感染而接受治疗的患者的住院记录。所有患者均接受了手术切开引流，并接受了静脉内抗生素治疗和住院治疗。通过拭子获得标本。
共纳入 206 例患者，分离出 251 株（每位患者 1.22 株）。108 株显示出抗生素耐药性。87 例患者至少有一种显示抗生素耐药性的细菌（42.2%）。最常分离出的细菌是链球菌属（n = 116），其抗生素耐药率很高（50.8%）。我们调查了 87 名患者中的 205 例抗生素耐药性。9 株细菌对万古霉素（unacid）无敏感性（4.3%），36 株对克林霉素（clindamycin）无敏感性（17.5%）。
克林霉素的抗生素耐药率相当高。受影响的空间和分离细菌的分布与最近的发现相似。必须认识到，立即进行手术切开引流是脓肿治疗的基础。抗生素治疗是辅助治疗。
链球菌属是最常被鉴定为具有抗生素耐药性的细菌，其耐药率超过 50%。克林霉素的耐药率增加需要重新考虑经验性抗生素治疗。
